Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
Department of Exercise Physiology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Abstract
Introduction: This study aimed to investigate the effect of running on a complex running wheel on hippocampus histology and memory function in rats model of Alzheimer's disease.
Methods: 24 rats were randomly selected and divided into three control (C), Alzheimer's control (AC), and Alzheimer's + complex wheel training (AT). To induce Alzheimer's disease in Alzheimer's groups, a mixture of ketamine (60 mg/kg) and xylazine (8 mg/kg) was injected into the hippocampus of rats. The AT group ran for 12 weeks on a complex running wheel, while the control groups (C and AC) were kept in cages for 12 weeks and did not participate in any training. In this research, the Tmaz test was used to test the spatial memory of rats. To analyze the data, a one-way analysis of variance was used at a significance level of 0.05.
Results: The results showed that running training has a significant effect on the hippocampal neuron density of rats. AT group showed higher neuron density than the C group. However, running training did not have a significant effect on the thickness of the hippocampal pyramidal layer of rats in the AT group, also, the difference between the AT and AC groups was not significant.
Conclusion: Running activity can increase the overall neuronal density of the hippocampus and thus help improve memory function in Alzheimer's patients.
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