The Effect of Eight Weeks of HIRT Training on the Serum Levels of Chemerin, Vaspin, and Factors Affecting the Pathogenesis of Diabetes in Obese and Overweight Pre-Diabetic Men

Al-Azi, Ahmed; Pourvaghar, Mohammad Javad; Bahram, Mohammad Ebrahim

doi:10.22059/jsb.2024.373767.1629

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ Department of Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.

² Corresponding Author, Department of Sports Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran.

³ Department of Exercise Physiology, Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran.

10.22059/jsb.2024.373767.1629

Abstract

Introduction: The expression of chemerin and Vaspin bioactive molecules is done through the communication between adipose tissue and other biological systems of the body, which play a role in the pathogenesis of metabolic syndrome, obesity, and diabetes. This study aimed to investigate the effect of eight weeks of HIRT training on the serum levels of Chemerin, and Vaspin, and factors effective in the pathogenesis of diabetes in obese and overweight pre-diabetic men.
Methods: In this semi-experimental study, 30 pre-diabetic obese men (30 to 45 years old) were randomly assigned to two experimental and control groups (15 people in each group). The experimental group participated in the HIRT program with an intensity of 80-85% of 1 repetition maximum for 8 weeks and three sessions each week for 60 minutes. The serum levels of Chemerin, Vaspin, and diabetes factors were measured on two occasions pre-test and post-test.
Results: The results of covariance analysis showed that the values of Chemerin (P=0.001), Vaspin (P=0.001), insulin (P=0.001), glucose (P=0.001), and insulin resistance (P=0.001), were significantly reduced in the experimental group compared to the control group. The intra-group results of paired t-test also showed a significant decrease in Chemerin (P=0.001, -0.90 percent), Vaspin (P=0.003, -16.6 percent), insulin (P=0.001, -17.5 percent), glucose (P=0.001, -19.1%), and insulin resistance (P=0.001, -40.8%) in response to the training protocol (P<0.05).
Conclusion: In general, HIRT training can have a beneficial effect on Chemerin, Vaspin, and some factors affecting diabetes and body composition in pre-diabetic obese men.

Keywords

Main Subjects

Exercise Physiology

References

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The Effect of Eight Weeks of HIRT Training on the Serum Levels of Chemerin, Vaspin, and Factors Affecting the Pathogenesis of Diabetes in Obese and Overweight Pre-Diabetic Men

References

References

[1]. Ghalandari K, Shabani M, Khajehlandi A, Mohammadi A. Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes. Archives of Physiology and Biochemistry. 2023; 2;129(1):76-81. DOI: 10.1080/13813455.2020.1797104

[2]. Daryanoosh F Sherafati Moghadam M B. Alizadeh Palavani h. The Effect of Aerobic and Anaerobic Exercises on Vaspin Level Plasma hormone Changes in Female Sprague Dawley Rats. Armaghane Danesh. 2014;19(8):717–26. http://armaghanj.yums.ac.ir/article-1-135-en.html [In Persain].

[4]. Saghebjoo M, Shabanpoor Omali J, Fathi R. Effects of 8 weeks high intensity circuit resistance training on plasma chemerin levels and glycemic control in male patients with type 2 diabetes. Olympic. 2013;21(5):99-113. DOI: 10.1007/s40200-023-01225-1 [In Persain].

[5]. Atya HB, Hassan ZA, Amin AI, Sae-M A. Vaspin concentration in obesity, impaired glucose tolerance and type 2 diabetes in Egypt. Adv Res Biol Sci. 2013;1:6–13. doi: 10.1155/2015/823481

[6]. Yang HW, Huang Yg, Gai Cl, Chai Gr, Lee S. Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus. Journal of Diabetes Investigation. 2021;12(4):566-73. DOI: 10.1111/jdi.13385

[8]. Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med [Internet]. 2010;1(3):151–8. doi: 10.5812/asjsm.34860

[9]. Wang HH, Chong M, Perrot N, Feiner J, Hess S, Yusuf S, Gerstein H, Paré G, Pigeyre M. Vaspin: A Novel Biomarker Linking Gluteofemoral Body Fat and Type 2 Diabetes Risk. Diabetes Care. 2024 1;47(2):259-66.

[10]. Wittenbecher C, Menzel J, Carstensen-Kirberg M, Biemann R, di Giuseppe R, Fritsche A, et al. Omentin-1, adiponectin, and the risk of developing type 2 diabetes. Diabetes Care [Internet]. 2016;39(6):e79-80. https://doi.org/10.2337/dc15-2702

[11]. Delpisheh A, Safarzade A. The effect of high-intensity interval training on serum and adipose tissues vaspin levels in rats fed a high-fat high-sucrose diet. Hormone Molecular Biology and Clinical Investigation. 2022;43(4):449-53. DOI: 10.1515/hmbci-2021-0107

[12]. Askari R, Ravasi AA, Gaieni AA, Hedayati M, Hamedinia MR. Effect of Combined and Endurance Exercise Training on Adipokines, GH and Lipid Profiles in Over weight Females. Journal of Sport Biosciences. 2015;6(4):399-413. doi.org/10.22059/jsb.2015.53211 [In Persain].

[14]. Hejazi m, nezamdoost z, Saghebjoo M. Effect of Twelve Weeks of Aerobic Training on Serum Levels of Leptin, Vaspin and Some Indicators of Oxidative Stress in Obese Middle-Aged Women. Iranian Journal of Endocrinology and Metabolism. 2014;16(2):111-8. [In Persain].

[15]. Wittamer V, Franssen J-D, Vulcano M, Mirjolet J-F, Le Poul E, Migeotte I, et al. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. The Journal of experimental medicine. 2003;198(7):977-85.

[16]. Pourvaghar M, Bahram M. The Effect of a Three-Month Intensive Intermittent Training on Plasma Chemerin and some Factors Related to Body Composition on Overweight Males. armaghanj 2015; 20 (5) :381-392 [In Persain].

[18]. Youn B-S, Kloting N, Kratzsch J, Lee N, Park JW, Song E-S, et al. Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes. 2008;57(2):372-7. doi.org/10.2337/db07-1045

[19]. Oberbach A, Kirsch K, Lehmann S, Schlichting N, Fasshauer M, Zarse K, et al. Serum vaspin concentrations are decreased after exercise-induced oxidative stress. Obesity facts. 2010;3(5):328-31.

[20]. Avansar MS. The effects of 8 weeks high intensity interval training on serum levels of TNF-α and insulin resistance index in obese men with type-2 diabetes. Medical Journal of Tabriz University of Medical Sciences. 2017;39(4):53-62. https://mj.tbzmed.ac.ir/Article/19465 [In Persain].

[21]. Yousefzadeh H, Ravasi A, Kordi M. Effect of High Intensity Interval Training on Chemerin Serum Concentrations and Insulin Resistance of Obese young Men. Journal of Sport Biosciences. 2022;14(1):1-13. doi.org/10.22059/jsb.2022.117054.883 [In Persain].

[22]. Faul F, Erdfelder E, Lang A-G, Buchner A. G* Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior research methods. 2007;39(2):175-91. https://link.springer.com/article/10.3758/BF03193146

[23]. Chemaitilly W, Li Z, Huang S, Ness KK, Clark KL, Green DM, et al. Anterior hypopituitarism in adult survivors of childhood cancers treated with cranial radiotherapy: a report from the St Jude Lifetime Cohort study. J Clin Oncol [Internet]. 2015;33(5):492–500. DOI: 10.1200/JCO.2014.56.7933

[24]. Wagner DR. ACSM’s resource manual for guidelines for exercise testing and prescription. Medicine & Science in Sports & Exercise. 2005;1;37(11):2018. healthworldeducation.org/?gad_source

[25]. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British journal of nutrition. 1978;40(3):497-504. DOI: 10.1079/bjn19780152

[28]. HAJINIA M, HAGHIGHI A, ASKARI R. The effect of high-intensity interval training and high-intensity resistance training on the Lipid profile and body composition in overweight and obese men. http://jms.thums.ac.ir/article-1-849-en.html [In Persain].

[29]. Ahmadizad S, Haghighi AH, Hamedinia MR. Effects of resistance versus endurance training on serum adiponectin and insulin resistance index. European journal of Endocrinology. 2007;157(5):625-32. https://doi.org/10.1530/EJE-07-0223

[32]. Venojärvi M, Wasenius N, Manderoos S, Heinonen OJ, Hernelahti M, Lindholm H, et al. Nordic walking decreased circulating chemerin and leptin concentrations in middle-aged men with impaired glucose regulation. Annals of medicine. 2013;45(2):162-70. doi.org/10.3109/07853890.2012.727020

[33]. Stefanov T, Blüher M, Vekova A, Bonova I, Tzvetkov S, Kurktschiev D, et al. Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine. 2014;45:382-91. https://link.springer.com/article/10.1007/s12020-013-0003-2

[34]. Neuparth MJ, Proença JB, Santos-Silva A, Coimbra S. The positive effect of moderate walking exercise on chemerin levels in Portuguese patients with type 2 diabetes mellitus. Journal of Investigative Medicine. 2014;62(2):350-3. https://doi.org/10.2310/JIM.0000000000000025

[35]. Lin X, Yang Y, Qu J, Wang X. Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ. Nutrition & metabolism. 2019;16(1):1-13. https://doi.org/10.1186/s12986-019-0344-9

[36]. Askari R, Ravasi A, Gaeini A. The effect of combined exercise training on some adipokines and insulin sensitivity index in overweight females. 2011;1(5):25-36. http://koomeshjournal.semums.ac.ir/article-1-4195-en.html [In Persain].

[38]. Rabe K, Lehrke M, Parhofer KG, Broedl UC. Adipokines and insulin resistance. Molecular medicine. 2008;14(11):741-51. doi: 10.2119/2008-00058.Rabe

[39]. Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, et al. Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism. Endocrine journal. 2013;60(1):37-44. https://doi.org/10.1507/endocrj.EJ12-0201

[40]. Habib S, Eshki A, AlTassan B, Fatani D, Helmi H, AlSaif S. Relationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women. Eur Rev Med Pharmacol Sci. 2017;21(6):1296-302. PMID: 28387898

[41]. Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. Journal of Biological Chemistry. 2007;282(38):28175-88.DOI:https://doi.org/10.1074/jbc.M700793200

[42]. Buechler C, Feder S, Haberl EM, Aslanidis C. Chemerin isoforms and activity in obesity. International journal of molecular sciences. 2019;20(5):1128. https://doi.org/10.3390/ijms20051128

[43]. Weigert J, Neumeier M, Wanninger J, Filarsky M, Bauer S, Wiest R, et al. Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes. Clinical endocrinology. 2010;72(3):342-8. https://doi.org/10.1111/j.1365-2265.2009.03664.x

[44]. Malin S, Navaneethan S, Mulya A, Huang H, Kirwan JP. Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. The journal of nutrition, health & aging. 2014;18:608-15. doi: 10.1007/s12603-014-0459-7

[45]. Barzegari A, Amouzad Mahdirejei H. Effects of 8 weeks resistance training on plasma vaspin and lipid profile levels in adult men with type 2 diabetes. Caspian journal of internal medicine. 2014;5(2):103-8. PMCID: PMC3992237

[46]. Kadoglou NP, Vrabas IS, Kapelouzou A, Angelopoulou N. The association of physical activity with novel adipokines in patients with type 2 diabetes. European journal of internal medicine. 2012;23(2):137-42. DOI: 10.1016/j.ejim.2011.10.020

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Volume 16, Issue 1 - Serial Number 99March 2024Pages 61-75

Volume 16, Issue 1 - Serial Number 99
March 2024
Pages 61-75