Sport Biosciences

Comparing Endurance and Resistance training on the Expression of Senescence-Related Genes in the Visceral Adipose Tissue of obese rats

Document Type : Research Paper

Authors

Nastaran Ghorbani Dasht Bayaz 1
adel donyaie 2
Elham Vosadi 3

1 Faculty of Physical Education and sport sciences, Shahrood University of Technology, Semnan, Iran.

2 assistant professor of Shahrood University of Technology

3 Assistant Professor of Sport Physiology Shahro University of Technology

https://doi.org/10.22059/jsb.2023.351533.1560
Abstract
Background: Positive regulation of senescence-related markers leads to adipose tissue disorders. Exercise seems to improve aging in adipose tissue.

Aims: The aim of this study was to compare the effect of endurance and resistance training on the expression of senescence-related genes.

Methods: In this experimental study, Twenty-four obese rats were divided into three groups: (1) Endurance Training, (2) Resistance Training, and (3) Control groups. Training groups trained for 8 weeks and 5 days a week. The Endurance group exercise program consists of Running on a treadmill and the Resistance group exercise program is included Climbing a resistance ladder. While, the control group had no training. The expression of P53, P16, and IL-6 genes in visceral tissue of obese rats were measured by Real-time PCR analysis. Finally, the data were analyzed by one-way ANOVA and Tukey post hoc test and statistical differences were considered significant at P<0.05.

Results: The results of this study showed the expression levels of P53, P16, and IL-6 genes in the Endurance Training group (P=0.001, P=0.006, P=0.001) and Resistance Training group (P=0.001, P=0.038, P=0.001) had a significant decrease compared to the control group. There was also no significant difference in the expression of P53, P16, and IL-6 genes between the endurance and resistance groups (P=0.439, P=0.584, P=0.300).

Conclusion: According to the results of the present study, it seems that endurance and resistance training plays a role in reducing the expression of senescence-related genes, which This effect was no different in endurance and resistance training.

Keywords

Senescence-Related Genes
Endurance Training
Resistance Training
Obese rats
Subjects

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  • Receive Date 15 April 2023
  • Revise Date 22 July 2023
  • Accept Date 01 August 2023

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