Sport Biosciences

The Simultaneous Effect of Aerobic Exercise and Rice Bran Extract Consumption on Inflammatory Genes Expression in White Adipose Tissue of Obese Female Rats

Document Type : Research Paper

Authors

Mojtaba Moazamigoodarzi 1
shahram gholamrezaei darsara 1
Mohammad Ali ََAzarbayjani 2
Alireza Elmiye 1

1 Department of Physical Education, Rasht Branch, Islamic Azad University, Rasht, Iran

2 Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

https://doi.org/10.22059/jsb.2023.354829.1578
Abstract
Introduction: Obesity and inflammation is an important risk factor for diseases. Aerobic exercise (AE) and medicinal herbs can reduce obesity-induced inflammation. This study aimed to investigate the effect of AE and Rice Bran Extract (RBE) on the inflammatory gene expression in white adipose tissue of obese female rats.
Methods: Thirty female Wistar rats were randomly divided into five groups including Control with a natural diet, Control with a High-Fat Diet (HFD), HFD + AE, HFD + RBE, and HFD + AE + RBE. Rats ran on a treadmill for four weeks and received RBE. To induce obesity, frying palm oil was used (0.5 ml/g). After euthanasia, the white adipose tissue was extracted to measure the IL6, TNF-α, and TLR4 gene expression.
 Results: HFD caused a significant increase in the IL-6, TNF-α, and TLR4 gene expression (P=0.001). AE significantly decreased IL-6 (P=0.001), TNF-α (P=0.041), and TLR4 (P=0.032) gene expression. RBE significantly decreased the IL-6 (P=0.001), TNF-α (P=0.003), and TLR-4 (P=0.011) gene expression. IL-6 (P=0.002), TNF-α (P=0.005), and TLR4 (P=0.011) gene expression was significantly decreased in the AE + RBE group compared to the control group with HFD, However, AE and RBE interaction in the expression of these genes was not statistically significant.
Conclusion: AE and RBE decrease the gene expression of inflammatory mediators caused by HFD in white adipose tissue. The AE and RBE consumption is recommended as a preventive and therapeutic solution in obesity conditions.

Keywords

aerobic exercise
rice bran
IL-6
TNF-a and TLR-4
Subjects

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  • Receive Date 05 March 2023
  • Revise Date 21 May 2023
  • Accept Date 27 May 2023

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