Lipocalin 2 and CTRP-12 are adipokines that are closely related to type 2 diabetes and are expressed in adipose tissue. Therefore, the purpose of this research is to investigate the effect of 12 weeks of resistance and aerobic exercise on the serum levels of CTRP-12 and LCN-2 in women with type 2 diabetes.Methods: The present study was conducted in a semi-experimental manner.The statistical population of the study was made up of all women with type 2 diabetes, from which 30 women with type 2 diabetes in the age range of 40-45 years were selected and randomly divided into three groups of resistance training (three with 10 repetitions and an intensity of 30 to 70% of 1RM), aerobic exercise and the control group. The training groups practiced for 12 weeks and 3 sessions per week. Serum levels of CTRP-12 and LCN-2 were measured using ELISA kit. To analyze the data, t-correlated and ANOVA statistical tests were used at a significance level of more than 5%
Results: The values of CTRP-12 in resistance and aerobic training groups increased significantly, while the values of LCN-2 in these two groups showed a significant decrease compared to the control group (p<0/05). In the intergroup analysis, resistance and aerobic training produced significant changes in CTRP-12 and LCN-2 compared to the control group.
Conclusion: It seems that performing resistance and aerobic exercises has an up-regulation of anti-inflammatory adipokines (CTRP-12) and a down-regulation of the inflammatory adipokine lipocalin-2 (LCN-2).