Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes

Fattahpour Marandi, Morteza; Babaei, Solmaz

doi:10.22059/jsb.2023.357093.1581

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

² Corresponding Author, Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran.

https://doi.org/10.22059/jsb.2023.357093.1581

Abstract

Introduction: Lipocalin-2 (LCN-2) and CTRP-12 are adipokines that are closely related to type-2 diabetes and are expressed in adipose tissue. Therefore, this research aimed to investigate the effect of 12 weeks of resistance and aerobic training on the serum levels of CTRP-12 and LCN-2 in women with type-2 diabetes.
Methods: The present research was conducted in a quasi-experimental manner. The statistical population of the study included all women with type-2 diabetes in Urmia city, from which 30 women with type-2 diabetes in the age range of 40-45 years old were selected and randomly assigned into three Resistance Training (three sets with 10 repetitions at 30 to 75% of 1RM), Aerobic Training (15 to 45 minutes at 50 to 75% of RHR), and Control groups. The training groups practiced for 12 weeks and three sessions per week. Serum levels of CTRP-12 and LCN-2 were measured using an ELISA kit. To analyze the data, dependent t, and ANOVA tests were used at a significance level of less than 5%.
Results: In the resistance and aerobic training groups, the values of CTRP-12 increased significantly, while the values of LCN-2 in these two groups decreased significantly compared with the control group (p<0/05). In the between-group analysis, resistance and aerobic training produced significant changes in CTRP-12 and LCN-2 compared with the control group (p<0/05).
Conclusion: It seems that performing resistance and aerobic training induces up-regulation of anti-inflammatory adipokines (CTRP-12) and a down-regulation of the inflammatory adipokine lipocalin-2 (LCN-2).

Keywords

Main Subjects

Exercise Physiology

References

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Effect of 12 Weeks of Resistance and Aerobic Training on Serum Levels of CTRP-12 and LCN-2 in Women With Type-2 Diabetes

References

References

[1] Shephard RJ. Obesity in 2018: Do we have an epidemic, and if so what caused it?. The Health & Fitness Journal of Canada. 2018 May 30;11(2):53-112. doi: 10.1038/nature18642

[2] Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, et al. The genetic architecture of type 2 diabetes. Nature. 2016;536(7614):41-9. doi: 10.1038/nature18642.

[3] Association AD. Diagnosis and classification of diabetes mellitus. Diabetes care. 2014;37(Supplement 1): S81-S90. https://doi.org/10.2337/dc14-s081.

[5] Scherer PE, Hill JA. Obesity, diabetes, and cardiovascular diseases: a compendium. Circulation research. 2016 May 27;118(11):1703-5. https://doi.org/10.1161/circresaha.116.308999.

[9] Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. Journal of Biological Chemistry. 2011 Oct 7;286(40):34552-8. https://doi.org/10.1074/jbc.m111.277319.

[10] Guo B, Li Y. GW26-e4592 Implication of C1q/TNF-related protein-12 (CTRP-12) in patients with coronary artery disease. Journal of the American College of Cardiology. 2015 Oct 20;66(16S):C67-c67. https://doi.org/10.1016/j.jacc.2015.06.1281.

[11] Tan BK, Chen J, Adya R, Ramanjaneya M, Patel V, Randeva HS. Metformin increases the novel adipokine adipolin/CTRP12: role of the AMPK pathway. J Endocrinol. 2013 Oct 4;219(2):101-8. https://doi.org/10.1530/joe-13-0277.

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[20] Rezaeian N, Ravasi AA, Soori R, Akbarnezhad A, Mirshafiey SA, Towfighi F. Effect of resistance training on serum levels of adipolin and insulin resistance in obese women. Journal of Sport Biosciences. 2020 May 21;12(1):1-6. https://doi.org/10.22059/jsb.2020.125058.936. (In Persian).

[21] Rahmatollahi M, Ravasi A, Soori R. Effect of 8 Weeks of Low-Intensity Continuous Training on Plasma Adipolin, Insulin Resistance, and Weight of Fatty Fat-Filled Rats. Adv Obes Weight Manag Control. 2017;7(5):00211. https://doi.org/10.15406/aowmc.2017.07.00211.(In Persian).

[23] Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, Baik SH, Choi DS, Kim SM. Effect of exercise training on A‐FABP, lipocalin‐2 and RBP4 levels in obese women. Clinical endocrinology. 2009 Apr;70(4):569-74. https://doi.org/10.1111/j.1365-2265.2008.03374.x

[24] Reilly T, Dowzer CN, Cable NT. The physiology of deep-water running. Journal of Sports Science. 2003 Dec 1;21(12):959-72. https://doi.org/10.1080/02640410310001641368.

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[28] Rahmatollahi M, Ravasi AA, Soori R, Onegh B, Dolati F. Adipolin and insulin resistance response to two types of exercise training in type 2 diabetic male rats. Endocrinol Metab Int J. 2018;6(1):36-40. https://doi.org/10.15406/emij.2018.06.00152. (In Persian)

[30] Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes care. 2003;26:S73. doi: 10.2337/diacare.26.2007.s73.

[31] Moghadasi M, Domieh AM. Effects of resistance versus endurance training on plasma lipocalin-2 in young men. Asian journal of sports medicine. 2014 Jun;5(2):108. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374613/ (In Persian).

[32] Owen HC, Roberts SJ, Ahmed SF, Farquharson C. Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. American Journal of Physiology-Endocrinology and Metabolism. 2008 Jun;294(6):E1023-34. https://doi.org/10.1152/ajpendo.00586.2007.

[33] Zhang J, Wu Y, Zhang Y, LeRoith D, Bernlohr DA, Chen X. The role of lipocalin 2 in the regulation of inflammation in adipocytes and macrophages. Molecular endocrinology. 2008 Jun 1;22(6):1416-26. https://doi.org/10.1210/me.2007-0420

[34] Domieh AM, Khajehlandi A. Effect of 8 weeks endurance training on plasma visfatin in middle-aged men. Brazilian Journal of Biomotricity. 2010;4(3):174-9. https://doi.org/10.1136/bjsm.2010.078725.68

Volume 15, Issue 2 - Serial Number 96May 2023Pages 43-55

Volume 15, Issue 2 - Serial Number 96
May 2023
Pages 43-55