Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Danesh Alborz, Univesity of Qazvin, Qazvin, Iran.

2 Corresponding Author, Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Bu-Ali Sina University of Hamedan, Hamedan, Iran.


Introduction: Hypertension and dyslipidemia are risk factors for cardiovascular diseases and are the leading causes of death. However, taking herbal supplements and physical activity engagement can help prevent this disease. Therefore, the present study investigated the effect of chitosan supplementation and combined exercise on blood pressure and lipid profile in women with hypertension.
Methods: The study was conducted as a clinical trial on 40 women with high blood pressure. The participants were randomly divided into four Chitosan Supplement (N=10), Combined Exercise (N=10), Chitosan Supplements + Combined Exercise (N=10), and Control (N=10) groups. For combined exercise, participants performed aerobic exercise for eight weeks (three days a week) followed by resistance training, while for the supplement, participants consumed four grams of Chitosan daily (eight capsules of  500 mg each). Blood sampling and blood pressure measurements were conducted before eight weeks and again 48 hours after the last exercise and supplementation session and all the measurements were recorded.
Results: Statistical analysis of data was done via SPSS version 23 using Analysis of Variance (ANOVA) and Covariance at a significant level of P≤0.05. The highest mean value of post-test systolic blood pressure (141.9±9.8), and post-test total cholesterol (213.28±3.9) was observed in the participants of the Combined Exercise group. The results of the between-group comparison indicated a significant improvement in systolic blood pressure, total cholesterol, triglyceride, VLDL, and LDL indices. In diastolic blood pressure and HDL indices, the results were close to the significant level.
Conclusion: Overall, the results showed that the consumption of Chitosan supplements and combined exercise have beneficial effects on the blood pressure and lipid profile of women with high blood pressure.


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