Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.

2 Corresponding Author, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran.


Introduction: Metabolic syndrome is a common metabolic disorder that occurs as a result of the prevalence of obesity. Studies showed that Beta-Aminoisobutyric Acid (BAIBA) plays a role in the regulation of lipid and carbohydrate metabolism in adipose tissue, liver, and skeletal muscles, and Angiopoietin-Like Protein 4 (ANGPTL4) plays a role in lipid metabolism and modulates metabolic control. This study aimed to investigate the effect of 12 weeks of aerobic training on ANGPTL4 and BAIBA serum levels in men with metabolic syndrome.
Methods: In this quasi-experimental study with a pre-test-post-test design, 20 people with whole conditions of metabolic syndrome, and with an age range of 40-60 years old were randomly divided into Control and Experimental groups (10 people in each group). The duration of aerobic exercise for these patients was more than or equal to 30 minutes in each session. The period was 45 minutes with 15 minutes of warm-up and cool-down, which was performed with moderate intensity and a sequence of three sessions per week for 12 consecutive weeks. Blood variables for ANGPTL4, and BAIBA serum concentration as well as metabolic risk indices were measured in the pre-test and post-test phases. Independent t-tests were used to examine the mean difference between the groups, pre- and post-exercise intervention, and t-tests and ANCOVA tests were used to compare the mean groups in each pre-test and post-test phase.
Results: As a result of exercise intervention in the experimental group, the amounts of BAIBA (P=0.001), VO2max (P=0.001), and ‌HDL (P=0.001) increased significantly; however, ANGPTL4 (P=0.001), BF (P=0.001), BMI (P=0.033), waist size (P=0.01), TG (P=0.015) LDL (P=0.009), TC (P=0.033) and insulin (P=0.001) decreased significantly in the exercise group compared with the control group (P<0.05).
Conclusion: Due to its positive effect on the serum levels of ANGPTL4, and BAIBA and also its effect on factors related to metabolic risk, aerobic training can be used as a method to activate the pathway of white to brown lipid conversion and improve indicators related to metabolic risk for men with metabolic syndrome.


Main Subjects

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