Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Department of Sports Physiology, Faculty of Humanities, University College of Omran_Toseeh, Hamedan, Iran

2 Corresponding Author, Department of Sports Physiology. Faculty of Humanities, University College of Omran_Toseeh, Hamedan, Iran

3 Department of Sports Physiology, Faculty of Sports Sciences, Bu Ali Sina University. Hamedan, Iran.



Background and purpose: Alzheimer's disease is a neurodegenerative disease. The present study was conducted to investigate the effect of twelve weeks of resistance training along with hawthorn consumption on some oxidative stress indicators in the serum of Alzheimer's male rats.

methods: In this study, 30 male Wistar rats were randomly divided into five groups of six. Healthy control, Alzheimer's control, Alzheimer's disease under resistance training, Alzheimer's disease under resistance training with hawthorn consumption, and Alzheimer's disease with hawthorn consumption were divided. Training was for 12 weeks and 5 days a week in the form of climbing a one-meter long ladder with weights attached to the rats' tails.The weight attached to the tail of each animal reached 50-60%in the first week and140-150%of the mice's weight in the last weeks.The group receiving the supplement received the mixture of hawthorn powder with the standard food of mice at a ratio of6.25%of hawthorn powder.24 hours after the last civilizing and supplemental intervention,the mice were unconscious and the serum levels of SOD,GPX,TACand MAD were determined by Eliezer method.Results:The results showed that resistance training, especially when taking hawthorn, led to a significant increase (P=0.002) in the serum level of glutathione peroxidase compared to other groups. However, no significant change was observed in the serum level of superoxide dismutase enzyme, total antioxidant capacity and lipid peroxidation in the experimental and control groups.

Conclusion: It is possible that resistance training and supplementation with hawthorn can be effective in adjunctive treatment in Alzheimer's patients, especially in the early stages.


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