The Effect of Moderate Resistance Training on Lymphocyte Cells ABCA1 Gene Expression, HDL and LDL in male with Coronary Artery Disease

Hajighasemi, Alireza; Ravasi, Ali Asghar; Kordi, Mohammad Reza; Rashidlamir, Amir

doi:10.22059/jsb.2022.206134.1075

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ Department of Sport Biosciences, Alborz campus, Tehran University, Tehran, Iran.

² Corresponding Author, Department of Sport Biosciences, Faculty of Physical Education and Sport Sciences, University of Tehran,

³ Department of Sport Biosciences, Faculty of Sport Sciences and Health, University of Tehran, Tehran, Iran.

⁴ Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.

https://doi.org/10.22059/jsb.2022.206134.1075

Abstract

Introduction: : One of the most important causes of cardiovascular diseases is atherosclerosis. Arteriosclerosis or atherosclerosis is the name of a disease in the vascular system, especially in the coronary arteries of the brain and heart, which is characterized by the deposition of lipids and other substances on the inner wall of the vessels. Atherosclerosis is the most important cause of death in the world. ABCA1 is the main responsible for the removal of cholesterol and phospholipid from the cell and the formation of HDL particles, and probably plays a role in the prevention and prevention of the spread of atherosclerosis. The aim of this study is the effect of cardiac rehabilitation training on ABCA1 gene expression.
Methods: Twentythree Myocardial infractions patients were randomly selected and assigned into two groups: control (N=11), and experimental (N=12). Blood sample of subjects were collected before and after exercise sessions. PBMN cells were separated and m-RNA purification was performed by Real–Time PCR. Data was analyzed by ANCOVA by SPSS software.
Results: Rehabilitation exercises increased ABCA1 gene expression and did not change HDL, LDL and RF ratio(P≤0.05).
Conclusion: In the end, the results of the research showed that cardiac rehabilitation exercises, which consisted of aerobic and light resistance exercises, in patients with arteriosclerosis, low intensity exercises caused a significant increase in ABCA1 gene expression in arteriosclerosis patients after 8 weeks, which probably It can be effective in reverse transfer of cholesterol and prevention of subsequent ischemia.

Keywords

References

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The Effect of Moderate Resistance Training on Lymphocyte Cells ABCA1 Gene Expression, HDL and LDL in male with Coronary Artery Disease

References

References

[1]. Jacobo-Albavera L, Domínguez-Pérez M, Medina-Leyte DJ, González-Garrido A, Villarreal-Molina T. The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease. International Journal of Molecular Sciences. 2021;22(4):1593.

[2]. Rashidlamir A. Investigation of the effect of aerobic and resistance exercises on peripheral blood mononuclear cells ABCG1 gene expression in female athletes. SSU_Journals. 2012;20(1):1-9. [In Persian].

[4]. Masuda D, Yamashita S. Very high levels of high-density lipoprotein cholesterol and cardiovascular events in Japanese population. Journal of Atherosclerosis and Thrombosis. 2016;23(7):771-2.

[5]. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[6]. Durstine JL, Grandjean PW, Davis PG, Ferguson MA, Alderson NL, DuBose KD. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports medicine. 2001;31:1033-62.

[7]. Yvan-Charvet L, Wang N, Tall AR. Role of HDL, ABCA1, and ABCG1 transporters in cholesterol efflux and immune responses. Arteriosclerosis, thrombosis, and vascular biology. 2010;30(2):139-43.

[8]. An F, Liu C, Wang X, Li T, Fu H, Bao B, et al. Effect of ABCA1 promoter methylation on premature coronary artery disease and its relationship with inflammation. BMC Cardiovascular Disorders. 2021;21(1):78.

[9]. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, et al. ABCA1 and ABCG1 protect against oxidative stress–induced macrophage apoptosis during efferocytosis. Circulation research. 2010;106(12):1861-9.

[10]. Gelissen IC, Harris M, Rye K-A, Quinn C, Brown AJ, Kockx M, et al. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arteriosclerosis, thrombosis, and vascular biology. 2006;26(3):534-40.

[11]. Ganjkhani L, Osali A. The Effect of 4 Week Resistance Training on Male Rat Hepatic ABCA1 Protein Plasma HDL-C Levels. Journal of Applied Health Studies in Sport Physiology. 2019;6(1):22-30. [In Persian].

[12]. Ikenaga M, Higaki Y, Saku K, Uehara Y. High-density lipoprotein mimetics: a therapeutic tool for atherosclerotic diseases. Journal of Atherosclerosis and Thrombosis. 2016;23(4):385-94.

[14]. Rashidlamir A, Dastani M, Saadatnia A, Bassami MR. Effect of cardiac rehabilitation training on ABCA1 expression in lymphocytes of patients undergoing coronary artery bypass graft operation. Zahedan Journal of Research in Medical Sciences. 2018;20(6). [In Persian].

[15]. Hoang A, Tefft C, Duffy SJ, Formosa M, Henstridge DC, Kingwell BA, et al. ABCA1 expression in humans is associated with physical activity and alcohol consumption. Atherosclerosis. 2008;197(1):197-203.

[17]. Ghanbari-Niaki A, Saghebjoo M, Hedayati M. A single session of circuit-resistance exercise effects on human peripheral blood lymphocyte ABCA1 expression and plasma HDL-C level. Regulatory peptides. 2011;166(1-3):42-7. [In Persian].

[18]. Rashidlamir A, Dorrudi S, Ebrahimiatri A. The Effect of One Session of Aerobic and Resistance Exercise on Lymphocyte ABCA1 Gene Expression in Well–Trained Girls. Journal of Sport Biosciences. 2012;4(12):5-22. [In Persian].

[21]. Okamoto T, Masuhara M, Ikuta K. Combined aerobic and resistance training and vascular function: effect of aerobic exercise before and after resistance training. Journal of applied physiology. 2007;103(5):1655-61.

[22]. Rashidlamir A, Ghanbari-Niaki A, Saadatnia A. The Effect of eight weeks of wrestling and wrestling technique based circuit training on lymphocyte ABCA1 gene expression and plasma apolipoprotein AI. World J Sport Sci. 2011;2(2):144-50. [In Persian].

[23]. Ghorbanian B, Ravassi A, Kordi MR, Hedayati M. The effects of rope training on lymphocyte ABCA1 expression, plasma ApoA-I and HDL-c in boy adolescents. International journal of endocrinology and metabolism. 2013;11(2):76. [In Persian].

[24]. Mostafavi S, Saeidi M, Heidari H. Effects of a comprehensive cardiac rehabilitation program on the quality of life of patients with cardio-vascular diseases. Journal of Research in Rehabilitation Sciences. 2012;7(4). [In Persian].

[25]. Borg GA. Physical performance and perceived exertion. 1962.

[28]. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2− ΔΔCT method. methods. 2001;25(4):402-8.

[29]. Sazegar M, Rashid Lamir A, Khajei R, Barjeste Yazdi A. Effect of a Combined Exercise Program on the Expression of ABCA5 Gene in White Blood Cells of Middle-aged Men After Coronary Artery Bypass Graft Surgery. Internal Medicine Today. 2021;28(1):86-97.

[30]. Wang J, Xiao Q, Wang L, Wang Y, Wang D, Ding H. Role of ABCA1 in Cardiovascular Disease. Journal of Personalized Medicine. 2022;12(6):1010.

[31]. Büttner P, Mosig S, Lechtermann A, Funke H, Mooren FC. Exercise affects the gene expression profiles of human white blood cells. Journal of applied physiology. 2007;102(1):26-36.

[32]. Demina E, Miroshnikova V, Rodygina T, Kurianov P, Vinogradov A, Denisenko A, et al. ABCA1 gene expression in peripheral blood lymphocytes and macrophages in patients with atherosclerosis. Molecular Biology. 2011;45:258-62.

[34]. Ghanbari-Niaki A. Treadmill exercise training enhances ATP-binding cassette protein-A1 (ABCA1) expression in male rats’ heart and gastrocnemius muscles. Int J Endocrinol Metab. 2010;8(4):206-10. [In Persian].

[35]. Ghorbanian B, Kordi MR, Ravasi AA, Hedayati M, Ghasemnian AA. The Effects of Eight weeks Interval Endurance Training on Lymphocyte ABCA1 protein Expression, Plasma Apolipoprotein AI and Lipid Profiles in Overweight and Obese Boy Adolescents. Journal of Sport Biosciences. 2015;7(3):375-90.

[36]. Von Eckardstein A, Nofer J-R, Assmann G. High density lipoproteins and arteriosclerosis: role of cholesterol efflux and reverse cholesterol transport. Arteriosclerosis, thrombosis, and vascular biology. 2001;21(1):13-27.

[37]. Fievet C, Castro G, James ER, Hennuyer N, Clee SM, Bissada N, et al. Increased ABCA1 activity protects against atherosclerosis. The Journal of clinical investigation. 2002;110(1):35-42.

Volume 16, Issue 1 - Serial Number 99March 2024Pages 5-15

Volume 16, Issue 1 - Serial Number 99
March 2024
Pages 5-15