Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
1 Associate Professor, Department of Physical Education and Sport Sciences, Faculty of Humanities, University of Kashan, Kashan, Iran
2 Ph.D, Candidate of Sports Physiology, Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, University of Mohaghegh Ardabili, Ardabil,Iran
Abstract
Myonectin is a myokine involved in metabolic processes associated with obesity. But the role of exercise on myonectin in obese adolescents has not been determined. The aim of this study was to investigate the effect of ten weeks of resistance training on the serum myonectin level and anthropometric indices related to weight loss in obese adolescents. In this quasi-experimental study, 16 obese male adolescents with mean age of 17.94±0.61 years and a body mass index between 30 and 35 kg/m2 were targeted selected and randomly divided into two equal experimental and control groups. The training group performed a resistance training program with an intensity of 40-85% of 1RM, for 10 weeks and 3 sessions per week. Before starting the training program and 48 hours after the last training session, serum myonectin levels and indices related to subjects' body composition were measured. Data analysis was performed using dependent t-test and analysis of covariance at a significance level of P=0.05. Data analysis showed that 10 weeks of resistance training significantly increased serum myonectin level (P=0.0001) in the experimental group compared to the control group. Also, the values of weight (P=0.015), body mass index (P=0.020) and fat percentage (P=0.0001) were significantly decreased in the experimental group (P<0.05). However, there was a significant difference between the experimental and control groups in the percentage of body fat (P=0.0001). However, no significant difference was observed between weight and body mass index (P<0.05). The results of this study showed that resistance training with an effect on the amount of myonectin can affect anthropometric indices related to overweight and obesity and can be effective in reducing the potential risk of some obesity-related diseases.
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- Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. The American journal of clinical nutrition. 2006;83(2):461S-5S.
- Stegen S, Derave W, Calders P, Van Laethem C, Pattyn P. Physical fitness in morbidly obese patients: effect of gastric bypass surgery and exercise training. Obesity surgery. 2011;21(1):61-70.
- Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in metabolism? Metabolism-Clinical and Experimental. 2013;62(8):1037-44.
- Pedersen BK. A muscular twist on the fate of fat. New England Journal of Medicine. 2012;366(16):1544-5.
- Pedersen BK, Febbraio MA. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nature Reviews Endocrinology. 2012;8(8):457-65.
- Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature medicine. 2011;17(11):1481-9.
- Peterson JM, Mart R, Bond CE. Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2014;2:e605.
- Seldin MM, Wong GW. Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 2012;1(4):200-2.
- Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. Journal of Biological Chemistry. 2012;287(15):11968-80.
- Raschke S, Eckel J. Adipo-myokines: two sides of the same coin—mediators of inflammation and mediators of exercise. Mediators of inflammation. 2013;2013.
- Shahidi f, Kashef M, Khaje Bahrami S. The effect of 4 and 6 weeks of resistance training on serum levels of myonectin and IGF-1 in sedentary young men. Razi Journal of Medical Sciences. 2019;25(10):31-7.
- Moein Farsani M JA, Fazel H. T. he effects of 8 weeks resistance training on serum myonectin and insulin resistance in obese women
- Safarzade A, Moazam-Vahid L. Effect of eight weeks resistance training on plasma myonectin concentration in obese men. Journal of Applied Exercise Physiology. 2016;12(24):119-28.
- Kazemi A, Mizani R. The comparison of different order of concurrent trainingon plasma myonectinlevels, insulin resistance index andanthropometric characteristics of elderly women. 2015.
- Park S-Y, Choi JH, Ryu HS, Pak YK, Park KS, Lee HK, et al. C1q tumor necrosis factor α-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. Journal of biological chemistry. 2009;284(41):27780-9.
- Vosadi E, Ravasi AA, Soori R, Mazaheri Z, Shabkhiz F. The effect of 4 weeks of endurance exercise on the expression of the muscle Myonectin levels and Insulin resistance in the adult rat. Pathobiology Research. 2016;19(2):89-97.
- Norheim F, Raastad T, Thiede B, Rustan AC, Drevon CA, Haugen F. Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. American Journal of Physiology-Endocrinology and Metabolism. 2011;301(5):E1013-E21.
- Committee IR. Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ)-short and long forms. http://www ipaq ki se/scoring pdf. 2005.
- Jackson AS, Pollock ML. Generalized equations for predicting body density of men. British journal of nutrition. 1978;40(3):497-504.
- Soheili S GA, Sori R. . . the effect of resistance training on systemic inflammation factors in old men. Olympic Journal 2009; 19(3): ( ):71-80..
- Gamas L, Matafome P, Seiça R. Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk. Journal of diabetes research. 2015;2015.
- Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. Journal of biological chemistry. 2013;288(50):36073-82.
- Kelley GA, Kelley KS. Impact of progressive resistance training on lipids and lipoproteins in adults: another look at a meta-analysis using prediction intervals. Preventive medicine. 2009;49(6):473-5.
- Ormsbee MJ, Thyfault JP, Johnson EA, Kraus RM, Choi MD, Hickner RC. Fat metabolism and acute resistance exercise in trained men. Journal of Applied Physiology. 2007.
- Pitsavos C, Panagiotakos DB, Tambalis K, Chrysohoou C, Sidossis L, Skoumas J, et al. Resistance exercise plus to aerobic activities is associated with better lipids’ profile among healthy individuals: the ATTICA study. QJM: An International Journal of Medicine. 2009;102(9):609-16.
- Donnelly JE, Smith B, Jacobsen DJ, Kirk E, DuBose K, Hyder M, et al. The role of exercise for weight loss and maintenance. Best Practice & Research Clinical Gastroenterology. 2004;18(6):1009-29.
- Sparti A, DeLany JP, Jacques A, Sander GE, Bray GA. Relationship between resting metabolic rate and the composition of the fat-free mass. Metabolism. 1997;46(10):1225-30.
- Fox AK, Kaufman AE, Horowitz JF. Adding fat calories to meals after exercise does not alter glucose tolerance. Journal of Applied Physiology. 2004;97(1):11-6.
- Lambers S, Van Laethem C, Van Acker K, Calders P. Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients. Clinical Rehabilitation. 2008;22(6):483-92.
- Zou C, Shao J. Role of adipocytokines in obesity-associated insulin resistance. The Journal of nutritional biochemistry. 2008;19(5):277-86.
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