Oxidative stress induced renal injures are intensified following myocardial infraction(MI) which are accompanied by an elevated NOX4 expression rate. However; the effect of exercise training following MI on blood Nox4 and renal oxidative stress markers have not investigated in spite of the apparent evidence regarding the effects of physical training on renal structure and function, which was investigated in this study.
24 male Wistar rats were randomized into three groups (n=8) of healthy control, MI control and MI training. Eight weeks of running training at moderate intensity on a treadmill was conducted following MI induction via two executive days’ injections of Isoproterenol (100 mg/kg.day). while renal MDA, cabonylated protein(CP) and 8OHdG levels via spectrophotometry and colorimetery
While blood NOx4 as well as renal MDA, CP and 8OHdG levels in MI control rats were higher than their healthy control littermates, the amount of these parameters (except for CP) in MI group was lower than healthy control group (p=0.001 in any circumstances). However, all indices including on blood NOX4 (p=0.029) and renal MDA(p=0.001), CP(p=0.001) and 8OHdG(p=0.019) levels in MI training rats was still higher than healthy control littermates.
MI is able to increase blood NOX4 level and incidence of renal oxidative stress. However, aerobic training could not fully ameliorate these hazardous effects of MI, in spite of its appreciable capabilities to reverse this trend. It seems that identification of the best effective training protocols in this area is warranted in addition to Eliminating the limitations in this study.