Sport Biosciences

The effect of a six-month combined care program with garlic supplementation on coagulation factors in middle-aged men with deep vein thrombosis

Document Type : Research Paper

Authors

Hamed Saed 1
Sedigheh Hosseinpour Delavar 2
Hassan Safikhani 3
Mohammadreza Sobhiyeh 4

1 1. PhD student ، Department of Exercise physiology ، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran

2 Assistant Professor، Department of Exercise Physiology، Kermanshah Branch، Islamic Azad University، Kermanshah، Iran (Corresponding Author)

3 Assistant Professor، Department of Corrective Exercises ، Kermanshah Branch ، Islamic Azad University ، Kermanshah ، Iran

4 Associate Professor , Department of Vascular & Endovascular Surgery, Clinical Research Development Center, Imam Reza Hospital، Kermanshah University of Medical Sciences ، Kermanshah , Iran

https://doi.org/10.22059/jsb.2022.325432.1475
Abstract
The purpose of this study was to compare the effect of six-months of combined care program with garlic supplementation on coagulation factors (INR, PPT, PT) in middle-aged men with DVT. The present study was a quasi-experimental with a clinical trial design (code: IRCT20210718051924N1). Subjects were 40 men (age: 51.50 ±4.01 years, fat percentage: 28.63 ±3.24) with a history of at-least 3 years of DVT who were taking warfarin randomly divided into four groups: Combined-exercise, Combined-exercise +garlic, Garlic and Control. Combined-exercise for 24 weeks, 3 sessions per-week, first resistance training (50 to 60% 1RM) and then aerobic training (55 to 60% of the reserve-heart-rate). 1200mg daily garlic supplement was used in the form of capsules at ten o'clock in the morning. PT, PTT and INR factors were measured before and after 24 weeks. Two-way analysis of variance, paired t-test and Tukey post-hoc test were used (P<0.05). The results showed that both combined-exercise +garlic and consumption of garlic increased the PT (garlic 3.3%, p=0.004; exercise +supplement 13.3%, P=0.001) and INR (garlic 2%, p=0.013; exercise +supplement 46%, p=0.001) had a significant effect, also combined-exercise +garlic on the PTT 1.5% (p=0.014) had a significantly effect. But this wasn’t of effects in the combined-exercises (PT: p=0.355, INR: p=0.259, PTT: p=0.448) and the group Garlic was-not significant in PTT (p=0.504). It is recommended to use combined exercises with garlic consumption because of its effect on PT and INR and the important role of these factors in rebalancing homeostasis.

Keywords

Combined Exercise
Deep Vein Thrombosis (DVT)
Coagulation Factors
Garlic Supplement
Subjects

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sport Biosciences
Volume 13, Issue 4
Autumn 2021
Pages 451-471

  • Receive Date 12 June 2021
  • Revise Date 03 December 2021
  • Accept Date 28 December 2021

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