The effect of 8 weeks of high-intensity interval training on vascular calcification index in mice with type 2 diabetes

Document Type : Research Paper


1 Faculty of physical education

2 Faculty of medicine


Aim: Diabetes mellitus (DM) is a chronic metabolic disease characterized by vascular classification and impaired carbohydrates, lipids, and lack of insulin secretion or decreased sensitivity to insulin metabolic effects. on the other hand, it seems the effect of exercise on vascular classification is an important issue. In the present study, we evaluated whether 8 weeks of high-intensity interval training (HIIT) decrease vascular calcification and improvement lipid profile in rats. Main Methods: 40 Male Wistar rats were randomly divided into diabetic (T2D), exercise-diabetic (EX –t2d), EXERCISE (EX), and control (Con) groups. After5 weeks, diabetes was induced in all the T2S and the EX-T2D group. The EX-T2D group trained for 8 weeks. Real-time PCR and colorimetric were performed to investigate the expression of RUNX and lipid profile Key Findings: Rat in the Typ2D group had a significant increase in glucose, triglyceride, cholesterol (p≤0.001), and LDL(p≤0.05) as well as deceased in insulin and HDL (p≤0.05). compared to the control group. In exercise, groups of rats had a significant decrease in RUNX expression compared to the control group (p≤0.05). in addition, Triglyceride and cholesterol levels were lower in the EXO-T2D group compared to the diabetes group (P≤0.05). Significance: Our data demonstrate that HIIT decreased vascular calcification and improved lipid profile in a mouse model of diabetes. However, further research is required to examine potential clinical relevance.


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