Sport Biosciences

The Effect of Combined Training and Vitamin D Supplementation on some Indicators of Liver Damage, Performance and Depression in Women Addicted to Methamphetamine and Heroin.

Document Type : Research Paper

Authors

Javad Vakili 1
Ramin Amirsasan 1
Rana Pourhasan 2

1 Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz, Iran.

2 Corresponding Author,Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz, Iran.

https://doi.org/10.22059/jsb.2021.322520.1464
Abstract
Introduction: This study aimed to determine the effect of eight weeks of combined training and vitamin D supplementation on some indicators of liver damage, performance, and depression of women addicted to methamphetamine and heroin.
Methods: In this quasi-experimental study design, 32 women addicted to methamphetamine and heroin, with an average age of 28.34 ± 6.7 years, an average weight of 62.06 ± 10.24 kg, and BMI of 24.10 ± 2.93 were voluntarily selected from Fereshteh quit addiction camp in Tabriz and were randomly divided into four groups of Training, Training + Supplement (vitamin D, 2000 IU per day), Supplement, and control. The combined training group program consisted of six circular resistance movements with an intensity of 40–70% of one-repetition maximum in stations and aerobic training with an intensity of 50–70% of heart rate reserve in the form of 5-minute aerobic intervals for eight weeks and three sessions per week. Before and after the training protocol, blood samples were taken from the volunteers to measure ALT, AST, and ALP enzymes. Cravings, depression, sports performance, and muscle endurance were also measured. The Shapiro-Wilk test was used to check the normal distribution of the data, and the Kruskal-Wallis and ANOVA tests with Bonferroni correction were used to compare the groups at a significance level of α<0.05.
Results: Liver AST and ALP enzymes showed a significant decrease in the Training + Supplement group compared with other groups (P=0.03). But ALT enzyme did not decrease significantly in all groups (P<0.05). Depression (P=0.01), craving (P=0.025), 600 m running, and muscular endurance were significantly improved in the Training group compared with the control group (P=0.001), but there was no significant difference in the supplement group compared with the control group (P <0.05).
Conclusion: Combined training along with Vitamin D supplementation can have beneficial effects on reducing liver damage and depression, and increasing muscle performance and endurance in addicted women.

Keywords

Addicted women
Combined exercise
Depression
Functional
Liver enzyme
Vitamin D
Subjects
  1. Emamipour S, Esfandabad HS, Sadrossadat S, Nejadnaderi S. Comparison of life quality and psychological disorders in drug-using, drug-using HIV infected, non-drug using HIV infected and a reference group of healthy men. J Shahrekord Uuniversity Med Sci. 2008;10(1):69–77. (In Persian).
  2. Wang K, Luo J, Zhang T, Ouyang Y, Zhou C, Lu Y. Effect of Physical Activity on Drug Craving of Women With Substance Use Disorder in Compulsory Isolation: Mediating Effect of Internal Inhibition. Front Psychol [Internet]. 2019 Sep 3;10.
  3. Winslow BT, Voorhees KI, Pehl KA. Methamphetamine abuse. Am Fam Physician. 2007;76(8).
  4. Bamdad M, Khoshknab MF, Dalvandi A, Ardakani MRK. Impact of Spiritual Care on Spiritual Health of hospitalized Amphetamin Dependents. Iran J Psychiatr Nurs. 2013;1(3):10–8. (In Persian).
  5. Tahamtan A, Tavakoli-Yaraki M, Mokhtari-Azad T, Teymoori-Rad M, Bont L, Shokri F, et al. Opioids and Viral Infections: A Double-Edged Sword. Front Microbiol [Internet]. 2016 Jun 22;7.
  6. Vozarova B, Stefan N, Lindsay RS, Saremi A, Pratley RE, Bogardus C, et al. High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes. Diabetes [Internet]. 2002 Jun 1;51(6):1889–95.
  7. Giannini EG. Liver enzyme alteration: a guide for clinicians. Can Med Assoc J [Internet]. 2005 Feb 1;172(3):367–79.
  8. Washton AM. Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors. J Stud Alcohol [Internet]. 1986 May;47(3):260–1.
  9. Hosseini SAA, Haghighi AH, Kakhk SAH. Effect of combined training with different intensities on pulmonary and physical function in addicted men. J Gorgan Univ Med Sci. 2018;20(3):56–63. (In Persian).
  10. Khatib AJ Al, Rawashdeh WS. The relationship between vitamin D deficiency with depression and addiction: review article. Eur Sci J [Internet]. 2014;10(24).
  11. Gorji HM, Rashidy-Pour A, Fathollahi Y, Semnanian S, Akhavan MM. Effects of voluntary exercise on severity of naloxone precipitated morphine withdrawal signs in rats. Koomesh. 2010;12(1):86–92. (In Persian).
  12. Skenderi KP, Kavouras SA, Anastasiou CA, Yiannakouris N, Matalas A-L. Exertional Rhabdomyolysis during a 246-km Continuous Running Race. Med Sci Sport Exerc [Internet]. 2006 Jun;38(6):1054–7.
  13. Suzuki A, Lindor K, Saver JS, Lymp J, Mendes F, Muto A, et al. Effect of changes on body weight and lifestyle in nonalcoholic fatty liver disease. J Hepatol [Internet]. 2005 Dec;43(6):1060–6.
  14. Ghaderi A, Banafshe HR, Motmaen M, Rasouli-Azad M, Bahmani F, Asemi Z. Clinical trial of the effects of vitamin D supplementation on psychological symptoms and metabolic profiles in maintenance methadone treatment patients. Prog Neuro-Psychopharmacology Biol Psychiatry [Internet]. 2017 Oct;79:84–9.
  15. Cass WA, Smith MP, Peters LE. Calcitriol Protects against the Dopamine- and Serotonin-Depleting Effects of Neurotoxic Doses of Methamphetamine. Ann N Y Acad Sci [Internet]. 2006 Aug 1;1074(1):261–71.
  16. Green M. RISK STRATIFICATION: Effective use of ACSM guidelines and integration of professional judgment. ACSMs Health Fit J [Internet]. 2010 Jul;14(4):22–8.
  17. Kaviani H, Mousavi AS. Psychometric properties of the Persian version of Beck Anxiety Inventory (BAI). Tehran Univ Med J TUMS. 2008;16(2):136–40. (In Persian).
  18. Farrokhyar F, Sivakumar G, Savage K, Koziarz A, Jamshidi S, Ayeni OR, et al. Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations and Physical Performance in Athletes: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Sport Med [Internet]. 2017 Nov 2;47(11):2323–39.
  19. Schumann M, Rønnestad BR. Concurrent Aerobic and Strength Training [Internet]. Schumann M, Rønnestad BR, editors. Cham: Springer International Publishing; 2019.
  20. Valente MJ, Araújo AM, Silva R, Bastos M de L, Carvalho F, Guedes de Pinho P, et al. 3,4-Methylenedioxypyrovalerone (MDPV): in vitro mechanisms of hepatotoxicity under normothermic and hyperthermic conditions. Arch Toxicol [Internet]. 2016 Aug 16;90(8):1959–73.
  21. Davoodi M, Moosavi H, Nikbakht M. The effect of eight weeks selected aerobic exercise on liver parenchyma and liver enzymes (AST, ALT) of fat liver patients. J Shahrekord Univ Med Sci. 2012;14(1):184–90.
  22. Farah Haddadi, Karimi MJ, Nejad MR, Sokhtehzari S, Monazami A, Asad M. The effect of endurance training on addicted women’s level of alkaline phosphates who use methadone. Rep Heal Care [Internet]. 2015;1(2):44–6. (In Persian).
  23. Abdollah J, Masoud H, Golmohammadian M. Effect of 8 Weeks Aerobic Exercise on Depression ’ s Level of Addicted during Treatment with Methadone. 2016;8(1):108–12.
  24. Mattson MP, Duan W, Wan R, Guo Z. Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations. NeuroRX [Internet]. 2004 Jan;1(1):111–6.
  25. Stokes CS, Grünhage F, Baus C, Volmer DA, Wagenpfeil S, Riemenschneider M, et al. Vitamin D supplementation reduces depressive symptoms in patients with chronic liver disease. Clin Nutr [Internet]. 2016 Aug;35(4):950–7.
  26. Wang D, Wang Y, Wang Y, Li R, Zhou C. Impact of Physical Exercise on Substance Use Disorders: A Meta-Analysis. Raju R, editor. PLoS One [Internet]. 2014 Oct 16;9(10):e110728.
  27. Rhodes JS, van Praag H, Jeffrey S, Girard I, Mitchell GS, Garland T, et al. Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci [Internet]. 2003;117(5):1006–16.
Sport Biosciences
Volume 14, Issue 2
Summer 2022
Pages 17-28

  • Receive Date 23 April 2021
  • Revise Date 07 October 2021
  • Accept Date 11 October 2021

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