Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license
Authors
1 isfahan
2 . Associate Professor, Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Abstract
Aim: The current study was aimed to investigate the effect of eight weeks of resistance training and coenzyme Q10 supplement on interleukin 4 and 10 levels and functional indices of skilled softball players.
Methodology: Twenty females Softball players from Isfahan were selected by available sampling method and randomly assigned into two groups of 10 players (experimental group; Q10 + resistance training) and (control group; placebo + resistance training). The intervention consisted of eight weeks of Q10 supplementation (a 200 mg capsule) and 2 sessions per week of resistance training along with specialized softball exercises. Before and after the 8-week intervention, agility, speed, vertical jump, sit-ups, and hand-grip power were evaluated, as well as the blood sampling was obtained from athletes
Results: Speed (P = 0.04 experimental; P = 0.02 control), agility (P = 0.03 experimental; P = 0.03 control), hand-grip power (P = 0.009 experimental; P = 0.01 control), sit-ups (P = 0.001 experimental; P = 0.003 control) and lactate dehydrogenase levels (P = 0.03 experimental; P = 0.03 control) significantly improved in both groups; however, Sargent's jump (P = 0.10 experimental; P = 0.89 control), creatine kinase (P = 0.67 experimental; P = 0.66 control), interleukin-4 (P = 0.32 experimental; P = 0.33 control) and interleukin-10 (P = 0.97 experimental; P = 0.08 control) did not alter in either group.
Conclusion: It appears that resistance training with Q10 supplementation along with specialized softball exercises is useful in developing some functional variables, especially abdominal endurance.
Keywords
Main Subjects
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261 ... تأثیر هشت هفته تمرین مقاومتی توانی و مصرف مکمل کیوتن بر میزان اینترلوکین 4 و 10
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262 علوم زیستی ورزشی، دورة 13 ، شمارة 2، تابستان 1400
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Fatty Liver Disease: A Double-Blind, Placebo-Controlled,Randomized Clinical Trial. J Am Coll Nutr. 2016; 35(4): 346–353. doi: 10.1080/07315724.2015.1021057 PMID:26156412 ( .in persian)
263 ... تأثیر هشت هفته تمرین مقاومتی توانی و مصرف مکمل کیوتن بر میزان اینترلوکین 4 و 10
29. Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013; 12(1): 142. doi: 10.1186/1475-2891-12-142 PMID: 24192015
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3. Farzanegi P, MohammadZadeh M. Interactive effect of exercise training with ω-3 supplementation on resting levels of TNF-α and IL-10 in Karat Men. Hormozgan Medical Journal, 2014. 18(1): p. 26-34. (in persian)
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261 ... تأثیر هشت هفته تمرین مقاومتی توانی و مصرف مکمل کیوتن بر میزان اینترلوکین 4 و 10
2012. Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity. J Interferon Cytokine Res.32 (1):12–17
5- Rethorst CD, Toups MS, Greer TL, Nakonezny PA, Carmody TJ, Grannemann BD, et al. Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder. Molecular psychiatry, 2013. 18(10): p. 1119-24.
6. Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, et al. Endothelial activation microparticles and inflammation status improve with exercise training in African Americans. International journal of hypertension, 2013. 2013: p. 1-8.
7. Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer J-M. IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. The Journal of clinical investigation, 1995. 96(5): p. 2304-10.
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10. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q10 effect on clinical improvement. PloS one, 2012. 7(4): p. e35677.
11. Hong KH, Cho ML, Min SY, Shin YJ, Yoo SA, Choi JJ, et al. Effect of interleukin‐4 on vascular endothelial growth factor production in rheumatoid synovial fibroblasts. Clinical & Experimental Immunology, 2007. 147(3): p. 573-9.
12. Rahimi R, Nejad HS. Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes. Preprints, 2017: p. 1-10.
13. Speretta GFF, Rosante MC, Duarte FO, Leite RD, Lino ADdS, Andre RA, et al. The effects of exercise modalities on adiposity in obese rats. Clinics, 2012. 67(12): p. 1469-77.
14. Habibi A, Abolfathi F, Nagafian N. [The effect of aerobic interval training on IL-6 and IL-10 serum concentration in women with type II diabetes ]. Journal of Arak University of Medical Sciences, 2016. 19(7): p. 36-45.(in persian)
15. Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, et al. Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q 10. British journal of nutrition, 2008. 100(4): p. 903-9.
16. Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, et al. Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals. Journal of the International Society of Sports Nutrition, 2008. 5(1): p. 8.
17. Moeini SM, Biglari G, Soheili S. Response of cortisol tnf-α, and plasma lactate levels, to the coenzyme q10 during exercise at a constant intensity in active females. Physiology of Sport and Physical Activity, 2016. 9(1): p. 1307-12.(in persian)
262 علوم زیستی ورزشی، دورة 13 ، شمارة 2، تابستان 1400
18. Changizi M, Ebrahimi M, SM. A. [Acute effects of coenzyme Q10 supplement on serum parameters of oxidative stress following one session of resistance training in male college athletes (In Persian)]. Koomesh, 2015. 16(4): p. 603-10.(in persian)
19- Hanachi P, Jalalvandi B, Nazarali P, Naghibi S. [The effects of coenzyme Q10 supplementation and aerobic training on HRDP and VO2max Women Active (In Persian)]. Journal of Arak University of Medical Sciences, 2014. 17(1): p. 12-24.(in persian)
20. Afshan S, Roshan VD. Comparing the effect of two resistance training with and without supplement ginger on inflammatory markers. Res Med, 2016. 40(3): p. 118-24.
21. Shirvani H, Nikbakht H, Ebrahim Kh GA. The effects of soccer specific exercise and Taurine supplementation on serum cytokine response in male elite soccer players. Ann Biol Res, 2012. 3(9): p. 4420-6.(in persian)
22. Rashidlamir A, Fazolahzade-Mousavi R, Mohammad Rahimi G. Effect of Eight Weeks of Aerobic Exercise on the Plasma Levels of Matrix Metalloproteinase in Life Guards: A Pilot Study. Health Education and Health Promotion, 2019. 7(2): p. 59-63.(in persian)
23. O'Connor M-F, Motivala SJ, Valladares EM, Olmstead R, Irwin MR. Sex differences in monocyte expression of IL-6: role of autonomic mechanisms. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2007. 293(1): p. R145-R51.(in persian)
24. Raygan F, Rezavandi Z, Dadkhah Tehrani S, Farrokhian A, Asemi Z. The effects of coenzyme Q10administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress in patients with metabolic syndrome. Eur J Nutr. 2015; 55(8):1–8( .in persian)
25. Esser N, Paquot N, Scheen AJ. Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs. 2015; 24(3): 283–307. doi: 10. 1517/13543784.2015.974804 PMID: 25345753
26. Nesami BN, Mozaffari-Khosravi H, Najarzadeh A, Salehifar E. The Effect of Coenzyme Q10 Supplementation on Pro-Inflammatory Factors and Adiponectin in Mildly Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled Trial. Int J Vitam Nutr Res. 2015; 85(3–4): 156–164. doi: 10.1024/0300-9831/a000234 PMID: 26780394( .in persian)
27. Soltani R , Muvahedi A. A review of the therapeutic effects of coenzyme Q10 on Parkinson's disease, Scientific conference of nutrition students.Tehran.2016; https://civilica.com/doc/474586. (in persian)
28. Farsi F, Mohammadshahi M, Alavinejad P, Rezazadeh A, Zarei M, Engali KA, Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Jm Coll Nutr. 2016; 35(4): 346–353. doi: 10.1080/07315724.2015.1021057 PMID: 26156412۶-Patients Affected by Nonalcoholic
Fatty Liver Disease: A Double-Blind, Placebo-Controlled,Randomized Clinical Trial. J Am Coll Nutr. 2016; 35(4): 346–353. doi: 10.1080/07315724.2015.1021057 PMID:26156412 ( .in persian)
263 ... تأثیر هشت هفته تمرین مقاومتی توانی و مصرف مکمل کیوتن بر میزان اینترلوکین 4 و 10
29. Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J. 2013; 12(1): 142. doi: 10.1186/1475-2891-12-142 PMID: 24192015
30. Parchmann CJ, McBride JM. Relationship between functional movement screen and athletic performance. The Journal of Strength & Conditioning Research, 2011. 25(12): p. 3378-84.
31. Mehrdad Fathi, Arash Mohammadi, Neda Badri, MohammadRahimi. GR. Implementation and measurement in physical education tests. 1st ed. Sabzevar: Beyhagh, 2020.(in persian)
32. Hemayat Talab R. Evaluation and measurement in physical education and sports science. Tehran: Elm va Harkat, 2013.(in persian)
33. Ali Asghar Mazani MRH, Amir Hossain Haghighi, Nosratollah Hedayatipour. [The Effect of 12 Weeks of Strength-Power Training with Different Loads on Muscular and Performing Functions in Soccer Players (In Persian)]. Journal of Sport Bioscience, 2017. 9(3): p. 315-32.(in persian)
34. Brzycki M. A practical approach to strength training: Masters Press Grand Rapids, MI; 1989.
35. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K. 2002. Systemic
inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev.8:6–.
36. Baranchi M, Kazemi A, Aghaalinejad H, Esfahani M, R. D. Different Responses of Interleukin-10 and Cortisol to Three Types of Sport Activity. Journal of Ilam University of Medical Sciences, 2014. 23(2): p. 1-11.
37. Forti LN, Van Roie E, Njemini R, Coudyzer W, Beyer I, Delecluse C, et al. Effects of resistance training at different loads on inflammatory markers in young adults. European journal of applied physiology, 2017. 117(3): p. 511-9.
38. Fatouros I, Chatzinikolaou A, Paltoglou G, Petridou A, Avloniti A, A. J. Acute resistance exercise results in catecholaminergic rather than hypothalamic pituitary adrenal axis stimulation during exercise in young men. Stress Amst Neth, 2010. 13: p. 461-8.
39. Kiyani N, Rahimi E, Hosseini SA, Z. M. The investigation of eight weeks of resistance training effect on 17-18-year-old boys’ interleukin-10, lymphocytes, monocytes and macrophages. Journal of Sport Bioscience Researches, 2014. 4(13): p. 39-50.(in persian)
40. Kjølhede T, Dalgas U, Gade AB, Bjerre M, Stenager E, Petersen T, et al. Acute and chronic cytokine responses to resistance exercise and training in people with multiple sclerosis. Scandinavian journal of medicine & science in sports, 2016. 26(7): p. 824-34.
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