Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Assistant Professor in Exercise Physiology, Department of Sport Sciences, Shirvan Branch, Islamic Azad University, Shirvan, Iran

2 Associate Professor in Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran

3 Assistant Professor in Exercise Physiology, Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran


ABCG8 is a cellular membrane transport protein that induces cholesterol efflux. The aim of this study was to investigate the effects of a period of cardiac rehabilitation on ABCG8 gene expression. 20 middle-aged men (50 to 60 years old) that experienced CABG, were assigned to two groups (control (n=10) and experimental (n=10)). Aerobic exercises were performed for 8 weeks (3 sessions per week) with the intensity of 11 to 13 (moderate intensity on the basis of Borg scale) under the control of a physician. Blood samples were collected after 12 to 14 hours of fasting 48 hours before and 48 hours after the exercises. RTPCR method was used to examine the gene expression of ABCG8 in both groups. Analysis of data using independent t test showed that ABCG8 gene expression in PBMN cells increased and lipid profile improved in experimental group (P≤0.05). According to research findings, ABCG8 gene expression after cardiac rehabilitation in PBMN cells is one of the mechanisms related to reverse cholesterol transport that can affect the prevention of recurrent myocardial infarction after CABG.


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