Comparison of four exercise training protocol for eight weeks on expression of some antioxidant enzymes in heart tissue of rats

Document Type : Research Paper


1 Associate Professor, Department of Physical Education and Sport Sciences, Payame Noor University, Tehran, Iran

2 . MSc, Department of Physical Education and Sport Sciences, Payame Noor University, Tehran, Iran

3 . Asistant Professor, Department of Physical Education and Sport Sciences, Payame Noor University, Tehran, Iran

4 Ph.D. Student of Exercise Physiology, Department of Exercise Physiology, Tehran Central Branch, Islamic Azad University, Tehran, Iran


Considering the importance of preventing heart disease and conflicting information about the effect of exercise training on glutathione peroxidase and catalase gene expression, the aim of this study was to investigate the effect offour training methods on Glutathione peroxidase and catalase expression in heart tissue of rats. For this purpose, 40 male wistar rats with age of 8-weeks were randomly divided into 5 groups including control group, moderate intensity training, high intensity training, high intensity interval training and moderate-intensity swimming training. To analyze of the data, one-way ANOVA and Tukey was used. The results showed that there was a significant increase in the Glutathione peroxidase and catalase expression as a result of all four exercise training program compared to the control group (P=0.001), Also, a significant increase in GPX expression was observed between HIIT and HIT groups compared to MIT and MIST groups (P=0.001). On the other hand, there was a significant increase in CAT expression between MIST group compared to MIT and HIIT groups (P=0.001 and P=0.030, respectively) and between HIT group compared to MIT and HIIT groups. There was also a significant difference between MIT and HIIT groups (P=0.001). All four training methods were able to improve the antioxidant system, causing favorable changes in the heart tissue of Wistar rats. It seems that HIT، HIIT & MIST by creating a beneficial adaptation in the antioxidant system, has made the body more resistant to the oxidative stress and has a more favorable effect on the heart tissue.


Main Subjects

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