The Effect of 6 Weeks of Aerobic Training and Aqueous Extract of Caraway Seed on Serum Level of Adipolin and Lipid Profile Changes in Obese Male Rats

Document Type : Research Paper


1 PhD of Exercise Physiology, Faculty Member of Department of Physical Education, Fatemeh Zahra Vocational School, Technical and Vocational University (TVU) , Kerman, Iran

2 Associate Professor, Department of Sport Sciences, University of Birjand, Birjand, Iran

3 Professor, Department of Physiology, Lorestan University of Medical Sciences, Lorestan, Iran

4 Assistant Professor, Department of Physiology and Pharmacology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran


Adipolin is an anti-inflammatory adipocytokine secreted from adipose tissue. Due to the role of medicinal plants in controlling obesity, this study was conducted to determine the effect of 6 weeks of aerobic training and aqueous extract of caraway seed on serum level of adipolin and lipid profile changes in obese male rats.In this experimental study, 24 obese male rats were used after 12 weeks of high-fat diet; they were randomly divided into 4 groups: 1. control 2. training 3. carawayextract 4. training + carawayextract. The training groups performed aerobic training for 6 weeks, 5 days a week (55% VO2max). Serum level of adipolin, lipid profile changes and body weight were measured. Data were analyzed using one-way ANOVA and Tukey's post hoc test. The results showed significant decreases in body weight, LDL-C, TG, TC (P<0.05) and significant increases in serum level of adipolin and HDL-C (P<0.05) in the training + carawayextract compared to other groups. According to the results, it seems that moderate intensity aerobic training and aqueous extract of caraway seed can lead to weight loss with an increase in serum level of adipolin and HDL-C and a decrease in LDL-C, TG and TC.


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