Effect of Resistance Training on Serum Levels of Adipolin and Insulin Resistance in Obese Women

Document Type : Research Paper


1 Assistant Professor, Department of Physical Education, Bojnourd branch, Islamic azad university of Bojnourd, Iran

2 Professor, Department of Exercise Physiology, Faculty of Physical Education,

3 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education, University of Tehran, Tehran, Iran

4 Professor, Department of pathobiology, School of public health and institute of health research, Tehran University of Medical Sciences, Tehran, Iran

5 PhD Student in clinical immunology, Tehran University of Medical Sciences, Tehran, Iran


Adipolin(CTRP12), is a novel anti-inflammatory adipokine improves Insulin sensitivity and decreases circulating glucose levels. This study investigated effect of strengthening training on adipolin levels and insulin resistance index (HOMA-IR) in obese women.20 sedentary postmenopausal obese women(BMI>30Kg/m2,aged 50-65 years) randomly assigned in to experimental(n=12)and control(n=8)groups.Subjects in experimental group participated in 12 weeks of strengthening training(3 sets of 8-12 repetitions at 40-60% of one maximal repetition),15-45 minutes per session and three sessions per week. Levels of adipolin, insulin and fasting glucose and anthropometric indices measured before and 48 hours after last training session. Statistical analysis was done by paired and independent t-test and Pearson correlation and P0.05). Therefore, strengthening training is one of treatment procedure to improve insulin sensitivity in sedentary postmenopausal obese women. However, more studied is necessary to identify molecular mechanism mediated by adipolin.


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