Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 MSc Student of Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran

2 Assistant Professor, Department of Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran

3 Associate Professor, Department of Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran


Purpose: Health professionals believe in the effective role of exercise training on improving the health of MS patients. The present study to investigate changes in serum levels IL4 and 17, as well as muscle strength changes after 8 weeks of regular resistance training. Methodology: The present study was a applied and pre-post design. Twenty-two women with multiple sclerosis in the range of 25 to 40 years old and with disability (EDSS = 4) were randomly assigned into experimental and control groups. 8-week training sessions, 3 sessions with 45-60% intensity, one repetition, performed exercises, and the control group did not participate in any regular physical activity. Before and after training, anthropometric tests, upper and lower strength and blood sampling were used to measure the levels of Interleukin 17 and 4. To determine the normal distribution of data, the Smirnov-Kolmogorov test and one-way variance analysis were used for the possible difference in the groups and the paired t-test was used to examine the intra-group changes. The significance level was considered to be P≤0 / 05 and the calculations were performed using SPSS version 18. Results: The statistical analysis showed that the subjects' strength was significantly higher than the control group (P = 0.001). Interleukin 4 showed a significant increase compared to the control group (P = 0.002), but interleukin 17 did not differ between the two groups. Women with multiple sclerosis seem to be able to use regular moderate-intensity exercise


1. Thompson AJ. Symptomatic management and rehabilitation in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry. 2001;71(suppl 2):ii22-ii7.
376 علوم زیستی ورزشی، دورة 11 ، شمارة 4، زمستان 1398
2. Browne P, Chandraratna D, Angood C, Tremlett H, Baker C, Taylor BV, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology. 2014;83(11):1022-4.
3. Motl RW, Snook EM, Wynn DR, Vollmer T. Physical activity correlates with neurological impairment and disability in multiple sclerosis. The Journal of nervous and mental disease. 2008;196(6):492-5.
4. Kolls JK, Lindén A. Interleukin-17 family members and inflammation. Immunity. 2004;21(4):467-76.
5. Paul WE. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood. 1991;77(9):1859-70.
6. Kvarnström M, Ydrefors J, Ekerfelt C, Vrethem M, Ernerudh J. Longitudinal interferon-β effects in multiple sclerosis: differential regulation of IL-10 and IL-17A, while no sustained effects on IFN-γ, IL-4 or IL-13. Journal of the neurological sciences. 2013;325(1-2):79-85.
7. Gutierrez GM, Chow JW, Tillman MD, McCoy SC, Castellano V, White LJ. Resistance training improves gait kinematics in persons with multiple sclerosis. Archives of physical medicine and rehabilitation. 2005;86(9):1824-9.
8. White LJ, Castellano V, Mc Coy SC. Cytokine responses to resistance training in people with multiple sclerosis. Journal of sports sciences. 2006;24(8):911-4.
9. Aidar FJ, Carneiro AL, Costa OM, de Oliveira Patrocínio C, Garrido ND, Machado VR, et al. Effects of resistance training on the physical condition of people with multiple sclerosis. The Journal of sports medicine and physical fitness. 2018;58(7-8):1127-34.
10. Dalgas U, Stenager E, Ingemann-Hansen T. Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance-and combined training. Multiple Sclerosis Journal. 2008;14(1):35-53.
11. Castellano V, Patel DI, White LJ. Cytokine responses to acute and chronic exercise in multiple sclerosis. Journal of Applied Physiology. 2008;104(6):1697-702.
12. Arellano G, Acuña E, Reyes LI, Ottum PA, De Sarno P, Villarroel L, et al. Th1 and Th17 cells and associated cytokines discriminate among clinically isolated syndrome and multiple sclerosis phenotypes. Frontiers in immunology. 2017;8:753.
13. Kordi M R, Anousheh L, Khodadad , Maghsoudi N, Sangolchi B, M H. Comparison of the effect of three methods of combined training on serum levels of ghrelin and pre-and anti-inflammatory cytokines in patients with multiple sclerosis (MS). Journal of Zanjan University of Medical Sciences. 1393;22 (91):39-51.(Persian).
14. Medicine ACoS. ACSM's guidelines for exercise testing and prescription: Lippincott Williams & Wilkins; 2013.
15. Brzycki M. Strength testing—predicting a one-rep max from reps-to-fatigue. Journal of Physical Education, Recreation & Dance. 1993;64(1):88-90.
16. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature reviews immunology. 2011;11(9):607.
و قدرت عضلانی در زنان مبتلا ... 377 IL17 , IL تأثیر هشت هفته تمرینات مقاومتی بر تغییرات 4
17. Brochu M, Malita MF, Messier V, Doucet E, Strychar I, Lavoie J-M, et al. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 2009;94(9):3226-33.
18. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clinica chimica acta. 2010;411(11-12):785-93.
19. Gold R, Lühder F. Interleukin-17—extended features of a key player in multiple sclerosis. The American journal of pathology. 2008;172(1):8-10.
20. Amedei A, Prisco D, D’Elios M. Multiple sclerosis: the role of cytokines in pathogenesis and in therapies. International journal of molecular sciences. 2012;13(10):13438-60.
21. Kjølhede T, Dalgas U, Gade AB, Bjerre M, Stenager E, Petersen T, et al. Acute and chronic cytokine responses to resistance exercise and training in people with multiple sclerosis. Scandinavian journal of medicine & science in sports. 2016;26(7):824-34.
22. Kim H-J, Kim J, Kim C-S. The effects of pilates exercise on lipid metabolism and inflammatory cytokines mRNA expression in female undergraduates. Journal of exercise nutrition & biochemistry. 2014;18(3):267.
23. Kraemer WJ, Ratamess NA. Fundamentals of resistance training: progression and exercise prescription. Medicine & Science in Sports & Exercise. 2004;36(4):674-88.
24. de Souza-Teixeira F, Costilla S, Ayan C, Garcia-Lopez D, Gonzalez-Gallego J, De Paz J. Effects of resistance training in multiple sclerosis. International journal of sports medicine. 2009;30(04):245-50.
25. Harvey L, Smith AD, Jones R. The effect of weighted leg raises on quadriceps strength, EMG parameters and functional activities in people with multiple sclerosis. Physiotherapy. 1999;85(3):154-61.
26. Heesen C, Gold SM, Hartmann S, Mladek M, Reer R, Braumann K-M, et al. Endocrine and cytokine responses to standardized physical stress in multiple sclerosis. Brain, behavior, and immunity. 2003;17(6):473-81.
27. Pérez CA, Sánchez VM, Teixeira FDS, Fernández JDP. Effects of a resistance training program in multiple sclerosis Spanish patients: a pilot study. Journal of sport Rehabilitation. 2007;16(2):143-53.
28. Kloubec JA. Pilates for improvement of muscle endurance, flexibility, balance, and posture. The Journal of Strength & Conditioning Research. 2010;24(3):661-7.
29. Schoenfeld BJ. The mechanisms of muscle hypertrophy and their application to resistance training. The Journal of Strength & Conditioning Research. 2010;24(10):2857-72.