Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish, Iran.

2 Corresponding Author, Department of Exercise Physiology, Kish International Campus, University of Tehran, Kish, Iran.

3 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.


Introduction: Aerobic exercises expand the capillary network in the heart and skeletal muscle. The present study aimed to investigate the effect of eight weeks of discontinuous aerobic exercises on serum vascular endothelial growth factor (VEGF) and serum endostatin (ES) in male rats with coronary artery disease.
Methods: The subjects were 30 two-month-old healthy male Wistar rats, which were divided into three groups including discontinuous aerobic exercise with coronary artery disease, the control group with coronary artery disease, and the healthy control group. After inducing disease in 20 rats with isoproterenol, 10 rats in the experimental group did discontinuous aerobic exercise on a treadmill for eight weeks, and the control group with disease (n=10) and the healthy control group (n=10) did not do any exercise. 72 hours after the last training session, to measure the serum indices of VEGF and ES, blood samples were drawn from the subjects. The one-way analysis of variance with Scheffe's post hoc test was used to compare the variables’ mean among the studied groups.
Results: The results showed that discontinuous aerobic exercise could increase the blood VEGF in rats with coronary artery disease (P=0.01) compared with healthy and diseased control groups, while there was no difference in the level of ES in groups (P>0.05).
Conclusion: It can be concluded from the present results that discontinuous aerobic exercises can be used in the rehabilitation of patients with coronary artery disease and are effective in the angiogenesis process.


Main Subjects

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