The Effect of Stevia Extract Consumption and Aerobic Exercise on Serum Omentin-1 and Lipid Profile in STZ Induced Diabetic Rats

Document Type : Research Paper


1 PhD Student, Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

2 Associate Professor; Department of exercise physiology, Faculty of Physical of Physical Education and Sport Sciences, Razi University , Kermanshah, Iran.

3 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Razi University , Kermanshah, Iran


Omentin-1 (adipokine derived from visceral adipose tissue) is associated with the development of diabetic disorders (such as insulin resistance and dyslipidemia). While aerobic exercises are employed due to their positive effects, new research has shown that medicinal plants are effective in improving the health and preventing and treating diabetes. One of these plants is the Stevia plant. The aim of this study was to investigate the effect of aerobic exercise and stevia extract consumption on serum omentin-1 and lipid profile in diabetic rats. 35 male rats (180-220 g weight range) were randomly divided into non-diabetic control, diabetic control, diabetic exercise, diabetic extract, and diabetic exercise along with stevia groups. Aerobic exercises included running on the treadmill, 5 days a week for 6 weeks and the extract was received in the same period. At the end of the intervention, blood samples were collected to measure the omentin-1 levels and lipid profile. Data were analyzed by one-way ANOVA and Tukey test.Results showed that omentin-1 levels in diabetic control group were lower than non-diabetic control group (P=0.001). The aerobic exercise program and stevia consumption significantly increased omentin-1 and HDL and significantly decreased TG, TC, LDL and VLDL in the experimental groups compared with the diabetic control group (P<0.05). These results indicated an increase in omentin-1 and improvement of lipid profile after aerobic exercise and stevia extract consumption. These effects were higher when exercise and stevia were used simultaneously.


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