The aim of this study was to determine the effect of 8 weeks of aerobic exercise on resistin, glycated hemoglobin, indicator of insulin resistance and some cardiovascular risk factors in obese women with type 2 diabetes. 22 obese sedentary women with type 2 diabetes in Kermanshah (mean age 44.95±2.33 yrs, weight 78.88±0.82 kg, height 161.11±5.45 cm) were randomly divided into 2 groups (each group 11 subjects): experimental and control. The experimental group performed aerobic exercises for 8 weeks (3 sessions per week, each session 60 minutes) with 60-80% of maximum heart rate. Blood samples were collected 2 days before and after the intervention. Independent t test was used to compare the intergroup differences and dependent t test was used to compare the intragroup results. After the intervention, weight, body fat percent, insulin, HbA1c, hc-CRP, LDL-C (P=0.05), fasting blood glucose (P=0.032), insulin resistance, resistin (P=0.04), cholesterol (P=0.028) and TG (P=0.014) significantly decreased in the experimental group compared to the control group. HDL-C and BMI levels had no significant differences between the groups. Weight (P=0.02), fat percent (P=0.01), glucose (P=0.004), insulin (P=0.031), resistin (P=0.024), TG (P=0.039), BMI, HbA1c, hc-CRP, LDL-C (P=0.05), insulin resistance and cholesterol (P=0.045) significantly decreased in the experimental group in the posttest compared with the baseline. The improved insulin resistance and decreased inflammatory markers and glycated hemoglobin reduce the potential risk of cardiac diseases and complications and diabetes and regular aerobic exercise can influence controlling the complications of this disease.