The Effect of Eight Week Interval training on The Serum VCAM-1 and PAI-1 in Obesity Women

Document Type : Research Paper


1 MSc, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran

2 Associate Professor, Department of Physical Education, Mahallat Branch, Islamic Azad University, Mahallat, Iran


The aim of this study was to investigate the effect of eight weeks of interval training on adiponectin, PAI-1, and VCAM-1 in sedentary middle-aged women. For this purpose, 40 sedentary middle-aged overweight women (BMI 25-30 kg/m2, age range 35-45 years) volunteered to participate in the study. They were divided into two groups: interval training (n=20) and control (n=20). Interval training group worked for 8 weeks (3 sessions per week, three 10-second speed intervals with 30-second rest intervals followed by three 30-second speed intervals with 90-second rest intervals). In order to increase overload, the number of intervals increased (an interval per week) after two weeks. Two days before and after the last training session, body composition and blood factors were measured in fasting state. Independent t test results showed that after 8 weeks of interval training, serum adiponectin level significantly increased compared to the control group (P<0.05) and serum VCAM-1 and PAI-1 levels decreased significantly. Also, body fat percentage, body mass index and waist circumference followed a period of interval training decreased and the maximum oxygen consumption increased (P<0.05). Therefore, it can be said that interval training increases adiponectin (a regulator of body metabolism); it also decreases VCAM-1 and PAI-1 which can improve the quality of life in sedentary obese women.


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