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Effect of High Intensity Aerobic Exercise Training and Arginine supplementation on Hormonal Changes in Leptin and Agouti-Related Protein (AGRP) in Obese Adolescent Boys

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

1 Ph.D. Student of Biochemistry and Sport Metabolism, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran

2 Associate Professor-Ferdowsi University of Mashhad

3 assisstant professor

4 Associate Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran

5 Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran

Abstract

Abstract
There is low information about the effects of high intensity aerobic exercise training (HIT) and the use of supplementation of arginine on appetite regulating hormones, along with nutritional control in obese adolescents. The purpose of this study was to determine the effect of eight weeks of HIT and supplementation of arginine on hormonal changes in leptin and agouti-related protein (AGRP) in obese adolescent boys. In isoenergetic conditions, 20 obese adolescents were according to aerobic power divided into two groups including: 1) HIT and placebo (C, n=10) and HIT with supplementation of arginine (T, n=10).Before Intervention exercise Protocol and 48 hours after the last exercise session, levels of appetite regulating hormones were measured in blood. For Investigation the differences between intra-and intergroup, Independent and independent Student was used. The results intra-and intergroup showed that there was no significant difference between leptin, AGRP compared to baseline levels among and between in C and T groups (P ≥0.05). Conclusion: Both exercise and supplement- exercises have different effects on the regulation of appetite in obese adolescent boys. However, the results of these works may not be palpable in some indices.

Keywords

References
  1. WHO. 2014. Global strategy on diet, physical activity, and health: childhood overweight and obesity. http://www.who.int/dietphysicalactivity/childhood/en/. [Accessed 20 November 2014.]
  2. Mirzaeian S, Fakhari M, Hosseini R, Hassanzadeh A, Esmaillzadeh A. Association between duration of breastfeeding and subsequent overweight and obesity in female adolescents. Iranian J Nutrition Sci & FoodTechnology 2011; 6(2): 65-74 .
  3. Azab, S.F.; Saleh, S.H.; Elsaeed, W.F.; Elshafie, M.A.; Sherief, L.M.; Esh, A.M. Serum trace elements in obese Egyptian children: A case-control study. Ital. J. Pediatr. 2014, 40, 20. [CrossRef] [PubMed]
  4. Mushtaq MU, Gull S, Abdullah HM, Shahid U, Shad MA, Akram J. Waist circumference, waist-hip ratio and waist-height ratio percentiles and central obesity among Pakistani children aged five to twelve years. BMC Pediatr. 2011; 11: 105.
  5. Han, J.C., Lawlor, D.A., and Kimm, S.Y.S. 2010. Childhood obesity. Lancet, 375(9727): 1737–1748. doi:10.1016/S0140-6736(10)60171-7. PMID:20451244.
  6. Woods SC, D`Alessio DA. Central control of body weight and appetite. J Clin Endocrinol Metab. 2008; 93:S37–S50. PubMed doi:10.1210/jc.2008-1630.
  7. Schwarz NA, Rigby BR, Bounty PL, Shelmadine B, Bourden RG. A review of weight control strategies andtheir effects on the regulation of hormonal balance. J Nutr Metab. 2011; 2011:2–15. doi:10.1155/2011/237932.
  8. Wagner LP, Mara CL, Thiago Ricardo ST, Babu B, Lila MO, Joao PB, James OH. Effect of Aerobic Exercise on Hunger Feelings and Satiety Regulating Hormones in Obese Teenage Girls. Pediatric Exercise Science, 2014, 26, 463-469.doi:10.1123/ 2013/0200© 2014 Human Kinetics, Inc.
  9. Varela L, Horvath TL. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep. 2012, (12) 13:1079-1086 .
  10. Russel RR, Willis KS, Ravussin E, Larson-Meyer ED. Effects of endurance running and dietary fat on circulating ghrelin and peptide YY. J Sports Sci Med 2009; 8:574–583. PubMed.
  11. Council on Sports Medicine and Fitness and Council on School Health (CSMFCSH). Active healthy living: prevention of childhood obesity through increased physical activity. Pediatrics. 2006; 117(5):1834–1842. PubMed doi:10.1542/peds.2006-0472.
  12. Martins C, Morgan L, Truby H. A review of the effects of exercise on appetite regulation: an obesity perspective. Int J Obes. 2008; 32(9):1337–1347. PubMed doi:10.1038/ ijo.2008.98.
  13. Silva A, Bloom SR. Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity. Gut Liver. 2012; 6(1):10–20. PubMed doi:10.5009/ gnl.2012.6.1.10.
  14. Konturek PC, Konturek JW, Czesnikiewicz-Guzik M, Brzozowski T, Sito E, Konturek SJ. Neuro-hormonal control of food intake: basic mechanisms and clinical implications. J Physiol Pharmacol. 2005; 56(6):5–25. PubMed.
  15. Varela L, Horvath TL. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Rep 2012;13(12):1079-86.
  16. Gutin B, Ramsey L, Barbeau P, et al. Plasma leptin concentrations in obese children: changes during 4-mo periods with and without physical training1–3. Am J Clin Nutr. 1999; 69:388–394. PubMed.
  17. Prado WL, Oyama LM, Lofrano-Prado MC. Alterations in Downstream Mediators Involved in Central Control of Eating Behavior in Obese Adolescents Submitted to a Multidisciplinary Therapy. J Adolesc Health. 2011; 49:300–305. PubMed doi:10.1016/j.jadohealth.2010.12.016.
  18. Reinehr T, Sousa G, Roth CL. Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweigh. Clin Endocrinol (Oxf). 2008; 68:304–310. PubMed.
  19. Angelopoulos N, Goula A, Tolis G. Current knowledge in the neurophysiologic modulation of obesity. Metabolism: Clinical and Experimental 2005; 54: 1202-17.
  20. Lau PWC, Kong Z, Choi C, et al. Effects of short-term resistance training on serum leptin levels in obese adolescents. J Exerc Sci Fit. 2010; 8(1):54–60. doi:10.1016/ S1728-869X(10)60008-1.
  21. Moore MS, Dodd CJ, Welsman JR, Armstrong N. Short-term appetite and energy intake following imposed exercise in 9- to 10-year-old girls. Appetite. 2004; 43(2):127–134. PubMed doi:10.1016/j.appet.2004.02.008.
  22. Terry EJ, Basilio JL, Brophy PM, McCammon MR, Hickner RC. Long-term Exercise Training in Overweight Adolescents Improves Plasma Peptide YY and Resistin. Obesity (Silver Spring). 2009; 17:1189–1195. PubMed.
  23. Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE. Three weeks of postweaning exercise in DIO ratsproduces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol. 2009; 296(3):R537–R48. PubMed doi:10.1152/ ajpregu.90859.2008.
  24. Letizia C, Petramala L, Di Gioia CRT, et al. Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia. J Clin Endocrinol Metab. 2014;100(1):E101-E4.
  25. Katzmarzyk PT, Malina RM, Bouchard C. Physical activity, physical fitness, and coronary heart disease risk factors in youth: the Quebec Family Study. Prev Med. 1999;29(6):555-62.
  26. Rashidlamir A, Ghanbari-niaki A. Effect of 8-week circuit training on lymphocyte AGRP gene expression in well-trained wrestlers. Daneshvar Med 2010;17(89):62-77.
  27. Moore MS, Dodd CJ, Welsman JR, Armstrong N. Short-term appetite and energy intake following imposed exercise in 9- to 10-year-old girls. Appetite. 2004; 43:127–134. PubMed doi:10.1016/j.appet.2004.02.008.
  28. Dodd CJ, Welsman JR, Armstrong N. Energy intake and appetite following exercise in lean and overweight girls. Appetite. 2008; 51:482–488. PubMed doi:10.1016/j. appet.2008.03.009.
  29. Lucotti P, Setola E, Monti LD et al. Beneficial effects of a long-term oral L -arginine added to a hypocaloric diet and exercise training program in obese, insulin-resistant 2 diabetic patients. Am J Physiol Endocrinol Metab. 2006; 291:E906–E912.
  30. Jobgen W, Meininger CJ, Jobgen SC et al. Dietary L–arginine supplementation reduces white fat gain and enhances skeletal muscl and brown fat masses in diet induced obese rats. JNutr2009a; 139:230–237.
  31. Jobgen W, Fu WJ, Gao H, Li P et al. High fat feeding and dietary L -arginine supplementation differentially regulate gene expression in rat white adipose tissue. Amino Acids. 2009b; 37:187–198.
  32. King DE, Mainous AG, Geesey ME (2008) Variation in L –arginine intake follow demographics and lifestyle factors that may impact cardiovascular disease risk. Nutr Res 28:21–24
  33. Jason R, McKnight M, Carey S, Wenjuan S, Jobgen S, Thomas E, Cynthia J, Catherine J, Guoyao W.Beneficial effects of L -arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids, 2010; 39:349–357 DOI 10.1007/s00726-010-0598-z.
  34. Prado WL, Lofrano MC, Cardel M, Balagopal P, Oyama LM, Gomes PP, Andrade M, Freitas C RM, Hill JO. Effect of a 12-Week Low vs. High Intensity Aerobic Exercise Training on Appetite-Regulating Hormones in Obese Adolescents: A Randomized Exercise Intervention Study. Pediatric Exercise Science, 2015; 27, 510 517.doi:10.1123/pes.2015-0018. Human Kinetics, Inc.
  35. Thivel D, Isacco L, Montaurier C, Boirie Y, Duché P, Morio B. The 24-h energy intake of obese adolescents is spontaneously reduced after intensive exercise: a randomized controlled trial in calorimetric chambers. PLoS ONE. 2012; 7:e29840. PubMed doi:10.1371/journal.pone.0029840.
  36. Howley ET, Bassett, Jr. DR, Welch HG. Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc. 1995; 27(9):1292–01. PubMed doi:10.1249/00005768-199509000-00009.
  37. Day JR, Rossiter HB, Coats EM, Skasick A, Whipp BJ. The maximally attainable VO2 during exercise in humans: the peak vs. maximum issue. J Appl Physiol. 2003; 95(5): 1901-1907. PubMed doi:10.1152/japplphysiol.00024.2003.
  38. WASSERMAN. K. Determinants and detection of anaerobic threshold and consequences of exercise above it.Circulation. 1949; 76(6):29–39.
  39. Jaak Jurimae, Toiv Jurimae. Ghrelin Responses to Acute Exercise and Training. Endocrinology of Physical Activity and Sport Contemporary Endocrinology 2013; 207-19.
  40. Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab 2002; 283: 861-65.
  41. Krashes MJ, Shah BP, Koda S, et al. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 2013;18(4):588-95.
  42. Horowitz JF. Fatty acid mobilization from adipose tissue during exercise. Trends Endocrinol Metab. 2003;14(8):386-92.
  43. Bailey DP, Smith LR, Chrismas BC, Taylor L, Stensel DJ, Deighton K, et al. Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. Appetite 2015; 89: 237-45.

 

Journal of Sport Biosciences
Volume 10, Issue 1
May 2018
Pages 133-148
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History
  • Receive Date: 30 January 2018
  • Revise Date: 26 June 2018
  • Accept Date: 25 June 2018
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