Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Ph.D. Student of Biochemistry and Sport Metabolism, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran

2 Associate Professor-Ferdowsi University of Mashhad

3 assisstant professor

4 Associate Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran

5 Professor, Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran


There is low information about the effects of high intensity aerobic exercise training (HIT) and the use of supplementation of arginine on appetite regulating hormones, along with nutritional control in obese adolescents. The purpose of this study was to determine the effect of eight weeks of HIT and supplementation of arginine on hormonal changes in leptin and agouti-related protein (AGRP) in obese adolescent boys. In isoenergetic conditions, 20 obese adolescents were according to aerobic power divided into two groups including: 1) HIT and placebo (C, n=10) and HIT with supplementation of arginine (T, n=10).Before Intervention exercise Protocol and 48 hours after the last exercise session, levels of appetite regulating hormones were measured in blood. For Investigation the differences between intra-and intergroup, Independent and independent Student was used. The results intra-and intergroup showed that there was no significant difference between leptin, AGRP compared to baseline levels among and between in C and T groups (P ≥0.05). Conclusion: Both exercise and supplement- exercises have different effects on the regulation of appetite in obese adolescent boys. However, the results of these works may not be palpable in some indices.


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