The Effect of high intensity interval training on the expression of the muscle myonectin levels and insulin resistance index in adult male Wistar rats

Document Type : Research Paper


1 PhD of Exercise Physiology, University of Tehran, Tehran, Iran

2 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 Assistant Professor, Department of Anatomy, Faculty of Medical Sciences, University of Tarbiat Modares, Tehran, Iran

4 Assistant Professor, Faculty of Physical Education and Sport Sciences, University of Shahrood, Shahrood, Iran


The aim of this study was to investigate the effect of four weeks of high intensity interval training on muscle myonectin gene expression and insulin resistance index, in the male adult rats. Fourteen Wistar rats (age: eight weeks) were divided into two groups: (1) interval training and (2) control groups. Animals in exercise groups received 4-wk interval training (five sessions per week) that included running on a treadmill and at the same time, the control group did not have any training. The soleus muscle homogenates and the expression of myonectin genes were measured by Real-time PCR analysis. The ELISA method for measuring insulin resistance index. The data were analyzed by Independent t-test. Statistical differences were considered significant at P



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