The Role of Orexin-A and HIF-1 Responses in Acute Mountain Sickness

Fayazi, Bayan; Tadibi, Vahid; Behpoor, Naser; Hedayati, Mehdi

doi:10.22059/jsb.2018.238223.1185

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

¹ university razi

² Associate Professor; Department of exercise physiology, Faculty of Physical of Physical Education and Sport Sciences, Razi University Kermanshah, Kermanshah, Iran.

³ Associate Professor, Faculty of Sports Sciences, Department of Exercise Physiology, Razi University, Kermanshah, Iran

⁴ Associate Professor, Faculty of Medical Sciences, Department of Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

https://doi.org/10.22059/jsb.2018.238223.1185

Abstract

Acute mountain sickness (AMS) caused by rapid ascent to altitudes higher than 2500 m has complex pathophysiological conditions. Therefore, the aim of the present study was to investigate hypoxia related factors in individual susceptible to acute mountain sickness. 21 healthy subjects (mean age 31.7±8.5 year) participated in this study. Fasting blood samples were collected from antecubital vein (sea level) 1 hour and 24 hours after rapid ascent to an altitude of 3550 m by a gondola lift. HIF-1 and Orexin-A were measured by ELISA method. AMS status was measured by the Lake Louise Scoring 6 hours after the exposure to a high altitude. Lake Louise Scoring showed that 11 subjects got AMS after the exposure to a high altitude (LLS≥4). The results showed that Orexin-A and HIF-1 at sea level were higher in AMS-susceptible subjects than AMS-resistant subjects. But Orexin-A and HIF-1 responses were almost higher in AMS-susceptible subjects than AMS-resistant subjects. Orexin-A and HIF-1 at sea level had an inverse relationship with AMS. An increase in these proteins in AMS-susceptible subjects was drastically higher than AMS-resistant subjects after exposure to altitude.

Keywords

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Journal of Sport Biosciences

The Role of Orexin-A and HIF-1 Responses in Acute Mountain Sickness

References

References

Volume 9, Issue 4
May 2016
Pages 529-541

The Role of Orexin-A and HIF-1 Responses in Acute Mountain Sickness

References

References

Volume 9, Issue 4May 2016Pages 529-541

Volume 9, Issue 4
May 2016
Pages 529-541