Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran


The aim of this study was to determine the effect of endurance training on some metabolic parameters of Nicotinamide and Streptozotocin induced type 2 diabetic rats. After the induction of diabetes (injection of Nicotinamide and Streptozotocin), 24 non-obese adult male rats were divided into 3 groups: non-diabetic (n=8), trained diabetic (n=8) and control diabetic (n=8). 4 weeks after the development of diabetes, the trained diabetic group ran on a treadmill for 4 weeks. At the end of the training, intraperitoneal glucose tolerance test was performed to determine insulin sensitivity. Plasma glucose and insulin levels were measured and HOMA-IR was calculated. Independent t test and two-way ANOVA were used to analyze data. Results indicated that during 4 weeks of diabetes induction, an insignificant difference was found in body weight, food intake and fasting plasma insulin level between diabetic and non-diabetic groups, but fasting and non-fasting blood glucose level significantly increased in diabetic group compared with non-diabetic group. After 4 weeks of training, an insignificant difference was found in body weight and food intake among non-diabetic, trained diabetic and control diabetic groups, but training significantly decreased fasting plasma glucose level and HOMA-IR and significantly increased fasting plasma insulin and glucose tolerance in trained diabetic group compared with control diabetic group. Therefore, it appears that 4 weeks of endurance training had beneficial effects on some metabolic parameters of type 2 diabetic rats.


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