Short-Term Effect of Two Types of High-Intensity Interval Training on Plasma Level of TNF-α, IL-6, CRP and Lipid Profile of Overweight Women

Document Type : Research Paper


1 Assistant Professor, Sport Sciences Research Institute of Iran, Tehran, Iran

2 M.Sc. of Exercise Physiology, Islamic Azad University, Karaj Branch

3 M.Sc. of Exercise Physiology, Islamic Azad University, Damghan Branch

4 M.Sc. of Exercise Physiology, Islamic Azad University, Sari Branch

5 Associate Professor in Biochemistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran


The aim of this study was to investigate the effect of 4 weeks of high-intensity interval training with weight-bearing and non-weight bearing on inflammatory markers of TNF-α, IL-6, CRP and lipid profile as predictive factors of the risk of cardiovascular diseases in overweight women. 16 non-athlete women (age 30 ± 5 yr, weight 75.48 ± 13.11 kg, height 165.50 ± 2.59 cm and body mass index 27.73 ± 4.20 Kg/m2) voluntary participated in the study. Subjects were randomly divided into two groups of high-intensity interval training: anaerobic RAST test and Wingate anaerobic test for 4 weeks, 3 sessions per week (between 3 and 6 Wingate test or RAST test each session). 24 hours before and 24 hours after training, blood samples was collected and the results were analyzed with Kolmogorov-Smirnov test, covariance analysis and paired t test at a significance level of P<0.05. The results indicated a significant reduction of plasma levels of TNF-α, IL-6 and CRP and an improvement in the lipid profile (excluding HDL-C) in both groups compared with the period before the training (P<0.05). However, after 12 sessions of training no significant difference was observed in inflammatory markers and lipid profile between the two group (P<0 .05). These findings suggest that even short periods of high-intensity interval training can reduce inflammatory markers associated with cardiovascular diseases although weight-bearing or non-weight bearing types of training do not make a significant difference.


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