Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 Ph.D. Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iranر

3 Ph.D. Student of Exercise Physiology, Baghiyatallah University of Medical Sciences, Tehran, Iran

4 Ph.D. Student of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran


The aim of this study was to investigate the effect of short-term taurine amino acid supplementation on neuromuscular fatigue and lactate accumulation after high intensity interval exercise. In this quasi-experimental study, the population consisted of physical education students. 20 male active volunteers (mean age, 22.12±1.25 years, height 174.59±4.63 cm, weight 71.52± 8.97 kg, BMI 23.40±2.19 kg/m2 and body fat percentage 11.81±1.21) in supplementation or placebo groups who were randomly selected participated in 2 sessions of pretest and posttest of maximal interval exercise. Taurine supplementation and placebo (starch) capsules (1 gram) were consumed by experimental and control groups, 5 capsules daily for 2 weeks. After the supplementation period, posttest was immediately conducted. To determine the differences between variables, ANOVA with the between-group and independent t test were used. The results showed that short-term taurine amino acid supplementation decreased neuromuscular fatigue (P=0.002) and blood lactate accumulation (P=0.000) following maximal interval exercise. Therefore, it can be reported that this supplement can be used to improve athletic performance in sprint interval activities.


  1. Abe, H. (2000). "Role of histidine-related compounds as intracellular proton buffering constituents in vertebrate muscle. " BIOCHEMISTRY C/C OF BIOKHIMIIA 65(7): 757-765.
  2. Bakker Anthony J and Helen M. Berg. (2002) “Effect of taurine on sarcoplasmic reticulum function and force in skinned fast-twitch skeletal muscle fibres of the rat”. Journal of Physiology, 538.1, pp. 185–194
  3. Balshaw Thomas G. et al 2012, “The effect of acute taurine ingestion on 3-km running performance in trained middle-distance runners”. Amino Acids, 1372-1, pp. 171–184
  4. Birdsall TC1998.: Therapeutic Applications Of Taurine. Altern Med Rev 3: 128–36,
  5. Bigland-Ritchie, B. , R. Johansson, et al. (1983). "Contractile speed and EMG changes during fatigue of sustained maximal voluntary contractions. " Journal of Neurophysiology 50(1): 313-324
  6. Bouchama A, El Yazigi A, Yusuf A, And Al Sedairy S1993: Alteration Of Taurine Homeostasis In Acute Heatstroke. Crit Care Med 21: 551–4,
  7. Dawson R, Jr., Biasetti M, Messina S, And Dominy J, 2002.: The Cytoprotective Role Of Taurine In Exercise-Induced Muscle Injury. Amino Acids 22: 309–24,
  8. El Idrissi A, And Trenkner E,2004.: Taurine As A Modulator Of Excitatory And Inhibitory Neurotransmission.Neurochem Res 29: 189–97,
  9. Girard, O. and G. P. Millet (2009). "Neuromuscular fatigue in racquet sports. " Physical Medicine and Rehabilitation Clinics of North America 20(1): 161-173.
  10. Goodman Craig A.,et al. 2009 “Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation” J Appl Physiol.107: 144–154,


  1. Haemi, et al. 2012 “The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes”. Pub med, 250- 258
  2. Hamilton, H. M. Berg, C. J. Easton, and A. J. Bakker. 2006” The effect of taurine depletion on the contractile properties and fatigue in fast-twitch skeletal muscle of the mouse” Amino Acids 31: 273–278
  3. Horne J. A. and L. A. Reyner,2001 ” Beneficial effects of an “energy drink” given to sleepy drivers”. Amino Acids 20: 83–89
  4. Levis, Scheller-, G.B, E. park. 2003. “ taurine: new implications for an old amino acid”. FEMS microbial Lett, 226(2): 195-202
  5. Matsuzaki Y, Miyazaki T, Miyakawa S, 2002: Decreased Taurine Concentration In Skeletal Muscles After Exercise For Various Durations. Med Sci Sports Exerc 34: 793–7,
  6. Matsumoto, T. , K. Ito, et al. (1991). "The relationship between anaerobic threshold and electromyographic fatigue threshold in college women. " European journal of applied physiology and occupational physiology 63(1): 1-5
  7. Rahnama, A. et al. 2010,” Effects of dietary supplementation of taurine, carnitine or glutamine on endurance exercise performance and fatigue parameters in athletes”. Appl sci, 57- 65
  8. Seidl, R, et al,2000,” a taurine and caffeine-containing drink stimulates cognitive performance and well being”. Amino acids, 19, 635-642
  9. Silva, Luciano A. Paulo C. L. Silveira, M. and et al. 2011” Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise. Cell Biochem Funct; 29: 43–49.
  10. Stipanuk MH,2004.: Role Of The Liver In Regulation Of Body Cysteine And Taurine Levels: A Brief Review. Neurochem Res 29: 105–10,
  11. Yatabe Y, Miyakawa S, Miyazaki T, Matsuzaki Y, And Ochiai N: 2003.Effects Of Taurine Administration In Rat Skeletal Muscles On Exercise. J Orthop Sci 8: 415–9,
  12. Zhang M, Izumi I, Kagamimori S, Sokejima S, Yamagami T, Liu Z, And Qi B: 2004.Role Of Taurine Supplementation To Prevent Exercise-Induced Oxidative Stress In Healthy Young Men. Amino Acids 26: 203–7,
  13. Zhang, M. I. Izumi, S. Kagamimori, S. Sokejima, T. 2002. Effects of taurine supplementation on VDT work induced visual stress. Amino Acids 26:59-63.