An Investigation of Response of FABP5 Plasma Levels to 8 Weeks of Aerobic Exercise in Non-Menopausal and Postmenopausal Overweight Women

Document Type : Research Paper

Authors

1 MSc, Faculty of Physical Education and Sport Sciences, Mazandaran University, Babolsar, Iran.

2 Associate Professor, Faculty of Physical Education and Sport Sciences, Mazandaran University, Babolsar, Iran

Abstract

 
The present study investigated the response of plasma levels of FABP5 to 8 weeks of aerobic exercise in women before and after menopause. 10 non-menopausal women (mean BMI ± SD, 27.8 ± 2.03 kg/m2) and 10 postmenopausal women (mean BMI ± SD, 28.6 ± 1.5 kg/m2) were assigned to two exercise groups. The program included 8 weeks of aerobic exercise, 3 sessions per week at 40-80% of maximal reserved heart rate. Each session lasted 25 minutes in the first week and it increased up to 45 minutes in the 8th week of exercise. Plasma levels of FABP5 and lipid profile were measured before and after the exercise period. The exercise significantly increased FABP5 in the postmenopausal group (P<0.05). LDL levels significantly increased in postmenopausal group and cholesterol was associated with a significant increase in both groups (P<0.05). Increasing levels of FABP5 in menopause may follow other mechanisms and be associated with metabolic changes after exercise.

Keywords

References

  1. Ayatollahi M. T, Ghaem H, Ayatollahi A. (2004). “Age of natural menopause and socio-population factors in shiraz 1379”. Jmums. 14(44): 51-61. (Persian)
  2. Bagheri, R., Qasim, A. N., Mehta, N. N., Terembula, K., Kapoor, S., Braunstein, S., . . . Reilly, M. P. (2010). “Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus”. American Journal of Cardiology. 106(8): 1118-1123.
  3. Carr, M. C. (2003). “The emergence of the metabolic syndrome with menopause”. Journal of Clinical Endocrinology & Metabolism. 88(6): 2404-2411.
  4. Dennis C.Y. Yeung, Yu Wang, Aimin Xu, Stephen C.W. Cheung, Nelson M.S. Wat, Daniel Y.T. Fong, Carol H.Y. Fong, M.T. Chau, Pak C. Sham, and Karen S.L. Lam. (2008). “Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio metabolic risk factors and carotid atherosclerosis”. European Heart Journal. 29: 2156-2163.
  5. Esteghamati A, Khalilzadeh O, Mohammad K, Meysamie A, Rashidi A, Kamgar M, et al. (2010). “Secular trends of obesity in Iran between 1999 and 2007: National Surveys of Risk Factors of Non communicable Diseases”. Metab Syndr Relat Disord. 8(3): 209-13.
  6. Esteghamati A, Khalilzadeh O, Rashidi A, Kamgar M, Meysamie A, Abbasi M. (2011). “Physical activity in Iran: results of the third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007)”. J Phys Act Health. 8(1): 27-35.
  7. Furuhashi, M., & Hotamisligil, G. S. (2008). “Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets”. Nature Reviews Drug Discovery. 7(6), 489-503.
  8. Furuhashi, M., Ishimura, S., Ota, H., & Miura, T. (2011). “Lipid chaperones and metabolic inflammation”. International journal of inflammation.
  9. Gertow, K., Pietiläinen, K. H., Yki-Järvinen, H., Kaprio, J., Rissanen, A., Eriksson, P., . . . Fisher, R. (2004). “Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance”. Diabetologia. 47(6): 1118-1125.
  10. Gregory B. Dwyer, Shala A Davies, Collector. (2008). ACSM's health-related physical fitness assessment manual. ACSM.
  11. Haider, D. G. Schindler, K. Bohdjalian, A. Prager, G. Luger, A. Wolzt, M. Ludvik, B. (2007). “Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight loss in obesity”. Diabetes, Obesity and Metabolism. 9: 761-763.
  12. Hanachi, P. (2008). “The Association of Hypertension with Major Risks Factors among University Putra Malaysia Retirees”. J. Med. Sci. 8(3): 254-261.
  13. Hassanzadeh J, Mohammadbeigi A, Eshrati B, Moemenbellah- Fard MD. (2012). “Estimation of the regional burden of noncommunicable diseases due to obesity and overweight in Mark-azi province, Iran, 2006-2007”. J Cardiovasc Dis Res. 3(1): 26-31.
  14. Hayat, I., Rowlands, D., Lys, I., Sukala, W., Cheema, B., Breier, B., Leikis, M., Krebs, J, and Page, R. (2012). “Effect of Aerobic Exercise on Leptin and PGC-1α Gene Expression in a Unique Cohort of Morbidly Obese Polynesians with Type 2 Diabetes”. Endocr Review. 33, MON-524.
  15. Hoekstra, M., Stitzinger, M., van Wanrooij, E. J. A., Michon, I. N., Kruijt, J. K., Kamphorst, J., . . . Kuiper, J. (2006). “Microarray analysis indicates an important role for FABP5 and putative novel FABPs on a Western-type diet”. Journal of lipid research. 47(10): 2198-2207.
  16. Irwin, M. L., Yasui, Y., Ulrich, C. M., Bowen, D., Rudolph, R. E., Schwartz, R. S., . . . McTiernan, A. (2003). “Effect of exercise on total and intra-abdominal body fat in postmenopausal women”. JAMA: the journal of the American Medical Association. 289(3): 323-330.
  17. Jackson AS, Pollock ML, Ward A. (1985). “Generalized equations for predicting body density of women”. Med Sci Sports Exerc. 12(3): 181-75.
  18. Jago, R., Jonker, M. L., Missaghian, M., & Baranowski, T. (2006). “Effect of 4 weeks of Pilates on the body composition of young girls”. Preventive medicine. 42(3): 177-180.
  19. Jakicic, J. M., Marcus, B. H., Gallagher, K. I., Napolitano, M., & Lang, W. (2003). “Effect of exercise duration and intensity on weight loss in overweight, sedentary women”. JAMA: the journal of the American Medical Association. 290(10): 1323-1330.
  20. JeVrey A. Potteiger. Randal P. Claytor. Mathew W. Hulver. Michael R. Hughes. Michael J. Carper. Scott Richmond. John P. Thyfault. (2012). “Resistance exercise and aerobic exercise when paired with dietary energy restriction both reduce the clinical components of metabolic syndrome in previously physically inactive males”. Eur J Appl Physiol. 112: 2035-2044.
  21. Kiens B, Alsted TJ, Jeppesen J. (2011). “Factors regulating fat oxidation in human skeletal muscle”. obesity reviews. 12: 852–858.
  22. Kraus WE, Houmard JA, Duscha BD, Knetzger KJ, Wharton MB, McCartney JS, et al. (2002). “Effects of the amount and intensity of exercise on plasma lipoproteins”. N Engl J Med. 347(19): 1483-92.

23.  Moghadasi, M. (2013). “Effects of 8 weeks high intensity aerobic exercise on serum adipocyte fatty acid binding protein levels”. annals of biological research. 4(12): 150-154.

  1. Nayebifar, S., Afzalpour, M., Saghebjoo, M., Hedayati, M., & Shirzaee, P. (2012). “The effect of aerobic and resistance trainings on serum C-Reactive Protein, lipid profile and body composition in overweight women”. Modern Care Journal. 8(4): 186-196.
  2. Olson TP, Dengel DR, Leon AS, Schmitz KH. (2007). “Changes in inflammatory biomarkers following one year of moderate resistance training in overweight women”. Int J Obesity. 31(6): 996-1003.
  3. Sori R, Khosravi N, Rezaeeyan N, Montazari Taleghani H. (2011). “Effect of combined endurance - resistance training on intercellular adhesion molecule and lipid profile in postmenopausal women 48-60 years”. MSPORT. 3(11): 61-80. (Persian)
  4. Strasser B, Siebert U, Schobersberger W. (2010). “Resistance training in the treatment of the metabolic syndrome: a systematic review and meta-analysis of the effect of resistance training on metabolic clustering in patients with abnormal glucose metabolism”. Sports Med. 40(19): 397-415.
  5. Timmons, J. A., Larsson, O., Jansson, E., Fischer, H., Gustafsson, T., Greenhaff, P. L., Wahlestedt, C. (2005). “Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy”. The FASEB journal. 19(7): 750-760.

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