The Eeffect of Caffeine Ingestion on Cortisol and Some Immune Factors Response to Exhaustive Exercise in Inactive Women

Document Type : Research Paper


Department of Sport Sciences, University of Bojnourd, Bojnourd, Iran


The aim of the present study was to investigate the effect of different doses of caffeine on cortisol and some immune factors response to exhaustive exercise in inactive women. For this purpose, 12 overweight inactive women were selected. This study was conducted in 4 stages with an observance of subjects' menopause. In the first stage, the participants consumed placebo and conducted Bruce exhaustive test after 30 minutes. In the second, third and fourth stage, they consumed 3, 6 and 9 mg/kg caffeine in the form of capsules and conducted Bruce exhaustive test after 30 minutes. Blood samples were collected immediately after Bruce test. For data analysis, repeated measures test was carried out at a significance level P<0.05. The results showed that cortisol levels were significantly higher in the third and fourth stages (medium and higher doses) than the first stage (P = 0.007 and 0.002 respectively). Leukocyte levels were significantly lower in the second and third stages (low and medium doses) than the first stage (P = 0.036 and 0.017 respectively). Lymphocyte levels were significantly higher in the third stage (moderate dose) than the first stage (P=0.025). Monocytes levels were significantly higher in the fourth stage (high dose) than the first stage (P=0.023). So, it seems that medium and high doses of caffeine (6 and 9 mg/kg) could have positive and beneficial effects on the immune system due to exhaustive exercise.


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