Document Type : Research Paper I Open Access I Released under CC BY 4.0 license


1 Associate Professor, Department of Exercise Physiology, Tarbiat Modares University, Tehran, Iran

2 Assistant Professor, Department of Exercise Physiology, Islamic Azad University, Borujerd Branch, Borujerd, Iran

3 Assistant Professor, Department of Physical Education, Lorestan University, Khoramabad, Iran


The aim of the present study was to investigate the effect of endurance training on SYD gene expression in motor neurons of rats with diabetic neuropathy. 12 Wistar male rats were randomly assigned to 3 groups (each group 4 subjects): diabetic trained (DT), diabetic untrained (DC) and healthy control (HC). Two weeks after STZ injection to induce diabetes, diabetic neuropathy was demonstrated by behavioral tests and endurance training protocol was performed. Then, L4-L6 motor neurons of spinal cord tissue were removed, and SYD gene expression was analyzed with Real time-PCR methods. The findings showed that mean SYD gene expression in DC group was significantly higher than HC group. Also, SYD gene expression in DT group was significantly lower than DC group. Generally, it can be concluded that in motor neurons of diabetic rats, mRNA SYD up-regulation is involved in neuronal injury signaling and training as a non-pharmacotherapy strategy can modulate it and get it close to normal levels.


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