A Study of the Effect of 10 Weeks of Resistance Training on HSP70 and Insulin Resistance in Type 2 Diabetic Women

Document Type : Research Paper




The aim of this study was to investigate the effect of 10 weeks of resistance training on serum levels of heat shock protein 70 (HSP70) and insulin resistance in type 2 diabetic women. 20 women with type 2 diabetes were selected by purposive sampling method and randomly divided into experimental group (n = 10, mean age 47.13±6.27 year, BMI 28.45±3.32 kg/m²) and control group (n = 10, mean age 50.30±9.97 year, BMI 28.78±2.45 kg/m²). The training program consisted of 10 weeks of resistance training, 3 sessions per week for 90 minutes at 8 stations with 30-80% one repetition maximum (1RM). After 12 hours of fasting, blood samples were collected 48 hours before the study and 48 hours after the last training session. Data were analyzed using theShapiro Wilk test and independent and dependent t tests with SPSS version 21 at significance level (α<0.05). The results showed that 10 weeks of resistance training in experimental group significantly decreased HSP70 levels, glucose and insulin resistance (P<0.05) whereas insulin levels did not change significantly (P>0.05). HSP70 and glucose changes from pretest to the posttest in the experimental group were significant compared with the control group (P<0.05). It seems that resistance training reduces fasting blood glucose and insulin resistance and increases levels of HSP70 in patients with type 2 diabetes; therefore, this training can be recommended as an adjuvant therapy in these patients.


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