Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


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2 Researcher


This study aimed at determining the chronic and acute effect of submaximal pedaling activity along with blood flow restriction on serum BDNF, TNF-α and BDNF/TNF-α ratio in active men. 24 physical education students at Kharazmi University volunteered for the study. They were divided into three groups: pedaling with lower extremity vascular occlusion (n=8), pedaling without occlusion (n=8), and control (n=8). Subjects in the occlusion and non-occlusion groups exercised for 3 weeks, 3 sessions per week (9 sessions totally). Each session included three 3-min. phases of pedaling at 50% of maximum power (Wmax) with 30–45 s rest interval between each two phases. The pressure on the thigh in the occlusion group was 140–170 mmHg. To analyze the data, one-way analysis of variance and independent and dependent t tests were used. Results showed that leg vessels occlusion during submaximal pedaling had no significant differences on response of BDNF (P=0.290)، TNF-α (P=0.338) and their ratio (P=0.384) compared with the non-occlusion group. In addition, in the compatibility phase, there were no significant differences in BDNF (P=0.254)، TNF-α (P=0.338) and their ratio (P=0.384) among occlusion, non-occlusion and control groups. Results showed that local blood flow restriction had no positive or negative effects on the amounts of BDNF, TNF-α and their ratio.


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