Document Type : Research Paper I Open Access I Released under CC BY 4.0 license


1 Associate Professor University of Mazandaran

2 teacher


The aim of this study was to investigate the effect of a period of swimming training on lung VEGF level in pregnant rats exposed to cadmium poisoning. 32 female Wistar rats were acclimatized with a new environment and water for 2 weeks; then, they had pregnancy and were divided into swimming, cadmium, cadmium - swimming and control groups. Swimming training started from the first day of pregnancy and it lasted 60 min./day in the second week of pregnancy. Samples of lung tissue were collected two days after delivery. Lung VEGF was determined by ELISA method. The data were analyzed by one-way analysis of variance and Tukey post hoc test at significance level of P≤0.05. Results showed that lung VEGF significantly decreased after delivery in cadmium group compared with the control group (P≤0.001). The difference of lung VEGF was not significant between swimming and control groups, but lung VEGF in cadmium - swimming group was significantly higher than cadmium group (P≤0.001). As cadmium inhibits lung angiogenesis activity during pregnancy, swimming can be beneficial to maintain the level of VEGF as a marker of angiogenesis.