Document Type : Research Paper I Open Access I Released under CC BY 4.0 license


1 - Associate Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 - PhD Student of Exercise Physiology, Shahid Rajaee Teacher Training University, Tehran, Iran

3 Assistant Professor, Department of Exercise Physiology, University of Valiasr, Rafsanjan, Iran

4 MSc of Exercise Physiology, University of Tarbiat Modares, Tehran, Iran

5 PhD of Exercise Physiology, University of Tarbiat Modares, Tehran, Iran


The incidence of obesity in children is increasing rapidly and it has been known that exercise training has beneficial effects on weight loss via modification of the synthesis factors of adipocyte.  The aim of this study was to assess the effect of 8 weeks of high intensity training (HIT) on serum levels of adiponectin and leptin in obese children. 17 obese children (mean age 9.58±0.35 and body mass index (BMI) 29.89±0.95) performed HIT including 30-second intensive running bouts and 1.5 min. of active rest for 8 weeks, 3 sessions per week. Number of bouts increased from 6 in the first week to 10 in the latter week. Results showed significant differences before and after HIT in leptin (P=0.001), adiponectin (P=0.0001) and BMI (P=0.0001). Also, there was a strong direct correlation between BMI and leptin (r=0.85) and reverse correlation with adiponectin (r= -0.68). HIT reduced BMI and body mass. Due to the strong relationship between BMI and selected adipokines, it can be stated that HIT can decrease serum levels of leptin and increase adiponectin in children via reduced fat mass. So, HIT with necessary cautions in obese children can have beneficial effects. 




    فخرزاده ح، حسین؛ قدسی، مریم؛ حمیدی، آناهیتا. رابطۀ نمایۀ تودۀ بدن با سطوح سرمی لپتین و ارتباط این دو با فشار خون در کودکان چاق. مجلۀ دیابت و لیپید ایران. 2005،5(1):75-82.

    1. 1.    Akbarpour M. The Effect of Aerobic Training on Serum Adiponectin and Leptin Levels and Inflammatory Markers of Coronary Heart Disease in Obese Men. Middle East Journal of Scientific Research. 2013;13(8).
    2. 2.                Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Müller J, et al. Plasma Leptin Levels in Healthy Children and Adolescents: Dependence on Body Mass Index, Body Fat Mass, Gender, Pubertal Stage, and Testosterone 1. Journal of Clinical Endocrinology & Metabolism. 1997;82(9):2904-10.
    3. 3.      Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. British journal of sports medicine. 2010;44(9):620-30.
    4. 4.    Ceddia R, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal
    5. 5.       De Araujo ACC, Roschel H, Picanço AR, do Prado DML, Villares SMF, de Sá Pinto AL, et al. Similar health benefits of endurance and high-intensity interval training in obese children. PloS one. 2012;7(8):e42747.
    6. 6.      De Feo P. Is high-intensity exercise better than moderate-intensity exercise for weight loss? Nutrition, Metabolism and Cardiovascular Diseases. 2013;23(11):1037-42.
    7. 7.        Dyck D, Heigenhauser G, Bruce C. The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiologica. 2006;186(1):5-16.
    8. 8.          Engelbregt MJ, van Weissenbruch MM, Popp-Snijders C, Lips P, Delemarre-van de Waal HA. Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction. Pediatric research. 2001;50(4):474-8.
    9. 9.           Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Molecular and cellular endocrinology. 2010;316(2):129-39.
    10. 10.                               Golbidi S, Laher I. Exercise Induced Adipokine Changes and the Metabolic Syndrome. Journal of Diabetes Research. 2014;2014
    11. 11.                           Kondo T, Kobayashi I, Murakami M. Effect of exercise on circulating adipokine levels in obese young women. Endocrine journal. 2006;53(2):189-95.
    12. 12.                          Kraemer RR, Chu H, Castracane VD. Leptin and exercise. Experimental Biology and Medicine. 2002;227(9):701-8.
    13. 13.                            Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nature medicine. 2004;10(7):739-43.
    14. 14.                             Patané G, Caporarello N, Marchetti P, Parrino C, Sudano D, Marselli L, et al. Adiponectin increases glucose-induced insulin secretion through the activation of lipid oxidation. Acta diabetologica. 2013;50(6):851-7.
    15. 15.                               Pilcova R, Sulcova J, Hill M, Blaha P, Lisa L. Leptin levels in obese children: effects of gender, weight reduction, and androgens. Physiological research. 2003;52(1):53-60.
    16. 16.                           Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, et al. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes care. 2003;26(8):2383-8.
    17. 17.                           Shalitin S, Phillip M. Role of obesity and leptin in the pubertal process and pubertal growth—a review. International journal of obesity. 2003;27(8):869-74.
    18. 18.                            Steinberg GR, Smith AC, Wormald S, Malenfant P, Collier C, Dyck DJ. Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle. American Journal of Physiology-Endocrinology And Metabolism. 2004;286(1):E57-E63.
    19. 19.                            Steinberg GR, Rush JW, Dyck DJ. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. American Journal of Physiology-Endocrinology and Metabolism. 2003;284(3):E648-E54.
    20. 20.                           Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, et al. Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. Journal of Biological Chemistry. 2004;279(29):30817-22.
    21. 21.                           Van Praagh E, Doré E. Short-term muscle power during growth and maturation. Sports Medicine. 2002;32(11):701-28.
    22. 22.                            Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes. 2001;50(12):2786-91.
    23. 23.                            Yadav A, Kataria MA, Saini V, Yadav A. Role of leptin and adiponectin in insulin resistance. Clinica Chimica Acta. 2013;417:80-4.

        You T, Nicklas BJ. Effects of exercise on adipokines and the metabolic syndrome. Current diabetes reports. 2008;8(1):7-11