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Effect of Berberis Vulgaris Supplementation on Glycemic Indices Patients with Diabetes Type 2 after one Session of Aerobic Exercise

Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license

Authors

1 Associate professor of sport physiology, Physical education and sport science faculty, Ferdowsi University of Mashhad, Mashhad, Iran

2 PhDStudent of sport physiology, physical education and sport science faculty, Ferdowsi University of Mashhad, Mashhad, Iran

3 PhD Student of sport physiology, physical education and sport science faculty, FerdowsiUniversity of Mashhad, Mashhad, Iran

Abstract

Abstract
Introduction: we researched to study the Effect of Berberis vulgaris supplementation on glycemic indices patients with diabetes type 2 after one session of aerobic exercise in accordance to independent effects of barberry extract and aerobic exercise.
Methods and material: 32 patient men with type 2 diabetes accidently divided into four groups of barberry extract (10 cc per 200 ml of water), exercise (60 to 70 of maxHR), combination of exercise and barberry extract and control. Glycemic indices were measured at the initiation of protocol and once at the end. Paired T test and ANOVA were used for data analysis.
Results: the following variable were reduced at the end in comparison to the primary assessment: serum glucose (barberry extract, exercise training and combination), glucolized hemoglobin (combination), insulin (exercise training and combination), insulin resistance (barberry extract, exercise training and combination)(P<0.05). Also the following variables are lower in comparison to control: serum glucose (combination), insulin (exercise training and combination), insulin resistance (combination) (P<0.05).
Conclusion: aerobic exercise and extract of barberry have independent beneficial effects on glycemic indices. However utilization of the both can amplify the effects to improve diabetes type2.
Keywords: Insulin, Type diabetes, Berberis vulgaris, Glucose, Insulin resistance, Aerobic exercise, Gelycolized hemoglobin.

Keywords

References
  1. Albright  A, Franz M, Hornsby G, Krika A, Marrero D, Ullrich I et al. Exercise and type 2 diabetes. Med sci sports Exrcise 2000; 32 (7): 1345-1360.
  2. American Diabetes Association. Standards of medical care in diabetes-2012. Diabetea Care 2012; 35(1)S11-S63.
  3. Arayne MS, Sultana N, SherBahadur S. The berberis story: Berberis vulgaris in therapeutics. Pak J Sci. 2007;20)1):83-92.
  4. Arora E, Shenoy S, Sandhu JS. Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res. 2009 May; 129(5): 515-9.
  5. Balducci S, Zanuso S, Nicolucci A, Fernando F, Cavallo S, Cardelli P, et al. (2010). Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. NutrMetabCardiovasc Dis, 20 (8): 608- 17.
  6. Bweir S, Al-Jarrah M, Almalty AM, Maayah M, Smirnova IV, Novikova L. Resistance exercise training lowers HbA1c more than aerobic training in adults with type 2 diabetes. DiabetolMetabSyndr. 2009 Dec; 10(1): 27.
  7. Carmen C, Jennifere L, Ledamunoz O, Patricial G, Joseph W, Mona F. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults.
  8. Casey L, Nicholas FT. Progressive resistance exercise improves glycemic control in people with type 2 diabetes mellitus: a systematic review. Australian Journal of Physiotherapy 2009; 55(4): 237-46.
  9. Cheng Z, Pang T, Gu M, Gao AH, Xie CM, Li JY, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMP and p38 MAPK. BiochimBiophysActa. 2006;11:1682–1689.
  10. Cho K, Kim YB. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med. 2010 Jun; 25(2): 119-29.
  11. Church TS, Blair SN, Coerham S, Johannsen N, Johnson W, Kramer K, et al. Effects of aerobic and resistance training on hemoglobin A12 Levels in patients with type 2 diabetes. JAMA 2010; 304(20): 2253-2262.
  12. Cuff DJ, Meneilly GS, Martin A, Ignaszewski A, Tildesley HD, and  Frohlich JJ.  Effective exercise  modality  to reduce insulin resistance in women with type 2 diabetes. Diabetes care 2003; 26: 2977-2982.
  13. Cui G,  Qin  X,  Zhang  Y,  Gong  Z,  Ge  B,  Zang  YQ.  Berberine  Differentially  Modulates  the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice. J BiolChem 2009; 284(41): 28420-9.
  14. Dela  F,  von  Linstow  ME,  Mikines KJ,  Galbo  H.  Physical  training  may enhance  beta-cell  function  in  type  2 diabetes.   Am   J   PhysiolEndocrinolMetabol 2004;287: E1024–31.
  15. DiLoreto  C,  Fanelli  C,  Lucidi  P,  Murdolo  G,  DeCicco  A,  Parlanti  N,  et  al.  Validation  of  a counseling  strategy  to  promote  the  adoption  and  the  maintenance  of  physical  activity  by  type  2 diabetic subjects. Diabetes Care 2003; 26, 404 – 8.
  16. Ebrahimi-Mamaghani M, Arefhosseini SR, Golzarand M, Aliasgarzadeh A, Vahed-Jabbary, M. Long-term Effects of Processed Berberis Vulgaris on Some Metabolic Syndrome Components. Iranian Journal of Endocrinology and Metabolism. 2010; 11(1): 41-47.
  17. Fatehi  M,  Saleh  TM,  Fatehi-Hassanabad  Z. A  pharmacological study on Berberis Vulgaris fruit extract. J Ethnopharm. 2005;102(10):46-52.
  18. Gao  CR,  Zhang  JQ,  Huang  QL.  Experimental  study  on  berberin  raised  insulin  sensitivity  in insulin resistance rat models. ZhongguoZhong Xi Yi Jie He ZaZhi. 1997; 17(3): 162-164.
  19. Giannopoulou I, ploutz-snyder LL, Carhart R, Weinstock RS, Fernhall B, Goulopoulou S et al. Exercise is required  for visceral fat loss in postmenopausal women with type 2  Diabetes. J ClinEndocrinolMetab 2005; 90: 1511-1518.
  20. Gloria  Y,  David  M,  Ted  J,  Russell  S.  Systematic  Review  of  Herbs  and  Dietary  Supplements for Glycemic Control in Diabetes. Diabetes Care 2003; 26: 1277–94.
  21. Hazaveyee  SM,  Torkman  A.  editors.  Exercise  andcuredisease. Hamedan: Chehr Publication.2002;P: 25-51.
  22. Hordern MD, Cooney LM, Beller EM, Prins JB, Marwick TH,  andCoombes  JS.  Determinants  of  changes  in  blood glucose   response   to   short-term   exercise   training   in patients with type  2 diabetes. Clinical  Science 2008;  115: 273-281.
  23. Hubinger  A,  Ridderskamp  I,  Lehmann  E.  Metabolic  response  to  different  forms  of  physical exercise in type i diabetics and the duration of the glucose lowering effect. Eur J Clin Invest 1985; 15: 197– 205.
  24. Ivanovska  N,  Phlipov  S.  Study  on  the  anti-inlammatory action of berberis vulgaris root extract, alkaloid fractions and pure alkaloid. Int J Ethnopharmacol. 1999;649(2):161-66.
  25. Izumi  T,  Suzuki  Y,  Fukunaga  T,  Yokozeki  T,  Akima  H,  Funato  K.  Resistance  training  affects glut-4  content in  skeletal muscle  of  humans  after  19  days  of  head-down  bed  rest.  J  Appl Physiology 1999; 86(3): 909– 14.
  26. Jae  SY,  Heffernan  KS,  Lee  MK, Fernhall   B,   Park   WH.  Relation   of cardio      respiratory      fitness      to  inflammatory    markers,    fibrinolytic actors  and  lipoprotein  (a)  in  patients with  type  2  diabetes  mellitus.  Am  JCardiol 2008;102:700-6.
  27. Jason J. Winnick W. Michael S, Diane L. Habash MB. Stout, Mark L, et al. Schuster short-term aerobic  exercise  training  in  obese  humans  with  type  2  diabetes  mellitus  improves  whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J ClinEndocrinolMetab 2008; 93: 771 –8.
  28. Kian bakht S. Systematic review on saffron sharmacology and its effective substance. Journal of Medical Plants 2008; 7(4): 1-27.
  29. Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S. Insulin  sensitizing  and  insulinotropic  action  of  berberine  from CortidisRhizoma. Biol Pharm Bull. 2005;28:1431–1437.
  30. Le  M,  Linda  M,  Von  D,  Serg  P.  Clinical  exercise        physiology.  Philadelphia: LWW; 2004.
  31. Li  SC,  Liu  YH,  Liu  JF,  Chang  WH,  Chen  CM,  Chen CY.  Almond  consumption  improved  glycemic  control and   lipid   profiles   in   patients   with   type   2   diabetes mellitus. Metabolism 2011; 60: 474-9.
  32. Majd A, Mehrabian S, Mostafai H, Rahmani H. Antioxidant and  anticancer  effect  of  aqueous  extract  of  berberisintegerrima.  J  of  biological  sciences.  2008;1:31-38.  [Article  in  Persian].
  33. Manson JE, Nathan DM, Krotewski AS.  A  prospective  study  of  exercise and  incidence  of  diabetes  among  U.S. male physicians. JAMA 1992; 268:637.
  34. Marcus  RL,  Smith  S,  Morrell  G,  Addison  O,  Dibble  LE,  Wahoff-Stice  D,  and  Lastago  PC.  Comparison  of  Combined aerobic  and  High–Force  eccentric  resistance  exercise  with aerobic exercise only for people with type 2 diabetes Mellitus. Physther 2008; 88: 1345-1354.
  35. Marwick   TH,      Hordern   MD,   Miller   T,   Chyun   DA,  Bertoni  AG,  Blumenthal  RS,    et  al.  Exercise  Training  for Type 2 Diabetes Mellitus: Impact on Cardiovascular Risk: A Scientific  Statement  From  the  American  Heart  Association. Circulation. 2009;119:3244-3262.
  36. Mauro  VF,  Taylor  ML,  Dawson  KL,  Tabb  NC.  A review  of  diabetes  mellitus  and  its  therapeutic options. The University of Toledo College of Pharmacy and College of Medicine 2006; 27- 41.
  37. Nawel M, Mohamed E, Amine D. Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats. Asian Pac J of Trop Biome. 2011;468-471.
  38. Nieman  DC.  Exercise  testing  and prescription. 5th ed. New York: Mhhe; 2003.
  39. Reynolds THIV, Supiano MA, Dengel DR. Regional differences in glucose clearance: effects of insulin and resistance training on arm and leg glucose clearance in older hypertensive individuals. J ApplPhysiol 2007; 102: 985–91.
  40. Roglic  G,  Unwin  N,  Bennett  PH,  Mathers  C,  Tuomilehto J, Nag S, et al. The burden of mortality attributable o  diabetes:  realistic  estimates  for  the  year  2000.  Diabetes Care 2005; 28: 2130-5.
  41. shamsi M, sharifirad G, kachoyee A, hassanzadeh A, The Effect of Educational Program Walking Based on Health Belief  Model  on  Control  Suger  in  Woman  by  Type  2 Diabetics    Iranian    Journal    of    Endocrinology    and Metabolism, 2010; 11 (5) :490-499.
  42. Shavandi  N,  Shahrjerdi  S, Sheikh  hoseini  R,  ghorbani  I.  The effect  of  strengthening  exercises on  metabolic  factors,  quality  of  life  and  mental  health  in  women  with  type  2  diabetes.  Iranian Journal of Endocrinology and Metabolism 2010; 12(3): 222-31.
  43. Shaw  JE,  Sicree  RA,  Zimmet  PZ.  Global  estimates  of the  prevalence  of  diabetes for  2010  and  2030.  Diabetes Res ClinPract 2010; 87: 4-14.
  44. Sigal  RJ,  Kenny  PK,  Boule  NG,  wells  GA,  prud'  home D, Fortier M, et al. Effects of aerobic Training, resistance training  a  both  on  Glycemic  control  in  type  2  diabetes. Ann Intern Med  2007; 147:357-369.
  45. Sori  R,  Rangbar  SH, Vahabi  K,  Shabkhiz  F. The  effet  of  aerobic training  on  serum  RBP4  and insulin  resistance  index  in  type  2  diabetic  patients.  Iranian  Journal  of  Lipid  and  Diabetic  2011; 10(4): 388-97.
  46. Sunmin P, Sang Mee H, JiEun L, So Ra S. Exercise improves glucose homeostasis that has been β impaired by a high-fat diet by potentiating pancreatic- cell function and mass through IRS2 in diabetic rats. J ApplPhysiol 2007; 103: 1764-71.
  47. Tadibi V, Bayat Z. Effect of eight weeks aerobic training and drug intervention on quality of life in women with type 2 diabetes. J GorganUni Med Sci 2012; 14(2): 30-6.
  48. Wang Y, Simar D, FiataroneSingh  M.  Adaptations to exercise training within skeletal muscle  in adults  with  type  2  diabetes  or  impaired  glucose  tolerance:  a  systematic  review.  Diabetes  Metab  Res Rev. 2009 Jan; 25(1): 13-40.
  49. Wild  S,  Roglic  G,  Green  A,  Sicree  R,  King  H.  Global prevalence  of  diabetes:  estimates  for  the  year  2000  and projections for 2030. Diabetes Care 2004; 27: 1047-53.
  50. Yavari  A,  Nagaphipour  F,  Asgarzadeh  AA,  Niafar  M,  Mobseri  M,  Nikokhoslat  S. The  effect  of aerobic,  resistance  and  combined  on  control  of  blood  glucose  and  cardiovascular  risk  factors  in type 2 diabetes patients. J Tabriz Med Sci 2011; 33(4): 82-91.
  51. Yin I, Hu R, Chen M, Tang J, Li F, Yang Y, et al. Effects of  berberine  on  glucose  metabolism  in  vitro.  Metabolism. 2002;51(11):1439-1443.
  52. Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, Chen J. Effects of berberine on glucose metabolism in vitro. Metabolism. 2002; 51(11): 1439-1443.
  53. Zhou L, Yang Y, Wang X, Liu S, Shang W, Yuan G, et al. Berberine  stimulates  glucose  transport  through  a  mechanism distinct from insulin. Metabolism. 2007;56:405–412.
Journal of Sport Biosciences
Volume 7, Issue 3 - Serial Number 3
October 2015
Pages 503-518
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History
  • Receive Date: 20 April 2014
  • Revise Date: 27 January 2016
  • Accept Date: 22 September 2014
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