The Effects of Eight weeks Interval Endurance Training on Lymphocyte ABCA1 protein Expression , Plasma Apolipoprotein A-I and Lipid Profiles in Overweight and Obese Boy Adolescents

Document Type : Research Paper


1 Assistant Professor, Physical Education and Sports Sciences Department, Faculty of Educational Sciences and Psychology, Azerbaijan Shahid Madani University, Tabriz, Iran

2 Associate Professor, Exercise Physiology Department, Physical Education and Sports Sciences Faculty, University of Tehran, Tehran, Iran

3 Professor, Exercise Physiology Department, Physical Education and Sports Sciences Faculty, University of Tehran, Tehran, Iran

4 Associate Professor of Biochemistry, Cellular-Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

5 Assistant Professor, Department of Exercise Physiology, Faculty of Humanities, University of Zanjan, Zanjan, Iran



Back grand: Early obesity and its transfer to the adult, increases likelihood incidence of coronary artery disease (CAD). ATP-binding cassette transporter) ABCA1) as a member of the ABC transporters family plays a crucial role in reverse cholesterol transport and CAD prevention.
Objective: The purpose of this study was to investigate ABCA1 expression in lymphocytes, plasma apolipoprotein A-I and lipid profiles in response to eight weeks interval aerobic endurance exercise as rope training.
Materials and Methods: Thirty students (17.3±1.1yr, 85.73± 11.68 kg and 28.41± 2.36 kg / m²) volunteered and randomly were assigned into training (n = 15) and control (n =15) groups. Exercise protocol was endurance rope training (8 wk, 4 d/wk and 40 min/d). cell hemolysis and sensitive Elisa method was used for Lymphocyte ABAC1 protein expression.T-student test was employed and data were analyzed by SPSS software (version 16).
Results: The independent-samples T-Test results were showed that after 8 weeks interval rope endurance training, the levels of lymphocyte ABCA1 expression(p=0/000) and VO2max(p=0/000) were significantly increased and plasma levels of TG(p=0.017), TC(p=0.001), LDL-c/HDL-c(0.026),TC/HDL-c(p=0.002) and measures of BF%(p=0/015)and BMI(p=0.042) as anthropometric indicators were decreased. Changes of other variables such increasing in Apo A-I , HDL-c, LDL-c and decreasing in body weight, were not significant. Significant level (p>0.05) was considered.
Conclusion: The findings of this study proved that 8-week interval aerobic endurance exercise as rope training can be have positive effects on lymphocyte ABCA1 protein expression(as goalkeeper of reverse cholesterol process) and lipid profiles and ultimately in prevention of arteriosclerosis among overweight and obesity adolescents.


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