The Effect of Concurrent (Resistance - Endurance) Training on Resting Levels of RBP4 and Insulin Resistance in Obese Middle-Age Men

Document Type : Research Paper

Authors

1 Associate Professor, Exercise Physiology Department, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 Professor, Exercise Physiology Department, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 M.Sc. of Exercise Physiology, University of Tehran, Tehran, Iran

Abstract

The aim of this study was to examine the effect of 12 weeks of concurrent training on RBP4 andinsulin resistance levels in obese middle-age men. For this purpose, 20 obese middle-age men voluntarily participated in this study and were assigned to concurrent training group (n=10, mean age 51.2 ± 2.25 yr and BMI 31.44 ± 0.81 Kg/m²) and control group (n=10, mean age 50.3 ± 2.11 yr and BMI 30.32 ± 1.34 Kg/m²). The concurrent group performed the 12-week protocol including resistance training (3 sessions per week, 50-75% of 1RM for 22 min.) and endurance training (running or walking with 50-80% HRmax for 22 min.). The results showed a significant decrease in RBP4 (P=0.003) and insulin resistance (P=0.019) after 12 weeks of concurrent training in comparison with the control group. It can be concluded that concurrent training can decrease RBP4 and insulin resistance levels. These changes may be in the line with subjects' weight loss.

Keywords


 
1- آذربایجانی، محمدعلی. عابدی، بهرام. پیری، مقصود. رسایی، محمدجواد. (1391). اثر یک جلسه تمرین ترکیبی مقاومتیو هوازی بر غلظت لیپتین سرم و شاخص مقاومت به انسولین در مردان غیرفعال. مجلۀ دانشگاه علوم پزشکی قم، دورۀ ششم، صص 46-43.
 
2-Assarzade Noushabadi, M. Abedi, B. (2012). Eeffect of combination training on insulin resistance index and some inflammatory markers in inactive men. PP:95.101
 
3-Azizi F, Azadbakht L, Mirmiran P.(2005). Trends in overweight, obesity and central fat accumulation among Tehranian adults between 1998–1999 and 2001–2002: Tehran lipid and glucose study. Ann Nutr Metab;49. PP:3 – 8
 
4-Chan JM, et al (1994) Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17.PP: 961–96
5- Choi, HY. Park, JW. Lee, N. Hwang, SY. Cho, GJ. Hong, HC. Yoo, HJ. Hwang, TG. kim, SM Baik, SH. Park, KS. Youn, BS. Choi, KM. (2013).Effect of a combined Aerobic and Resistance Exercise Program on C1q/TNF-Related Protein-3 (CTRP-3) and CTRP-5 Levels. Diabetes Care .PP: 36(10):3321-7
 
6-. Cho, YM.. Youn BS, Lee.H. Lee N, Min SS, Kwak SH, Lee HK, Park KS:(2006).Plasma retional binding protein 4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes.Diabetes Care 29.PP:2457-2461
 
7-. Choi, KM.. Kim, TN.. Yoo, HJ.. Lee, KW.. Cho, GJ. Hwang, TG. Baik, SH.. Choi DS ands. Kimt, M. (2009) Effect of exercise training on A-FABP,lipocalin-2 and RBP4 levels in obese women.Clin Endocrinol (Oxf).70(4) .PP:569-74.
 
8-Colditz GA, Willett WC, Rotnitzky A, Manson JE 1995 Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122:PP 481– 486
9- Dadamo E, Santoro N & Caprio S. 2009. Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed. Endocrinology and Metabolism Clinics of North America  .PP: 38549 –563
10-. Davidson LE; Hudson R, Kilpatrick K,. Kuk JL,; McMillan. K,;. Janiszewski PM,; Lee, S; Lam. Miu, Ross R, (2009) Effects of Exercise Modality on Insulin Resistance and Functional Limitation in Older Adults Arch Intern Med.;169(2) PP :122-131
11-Ferrannini E, Gastaldelli A,Miyazaki Y.,Matsuda M., Mari A., DeFronzo R.A., (2005) Beta-cell function in subjects spanning the range fromnormal glucose tolerance to overt diabetes: a new analysis, J Clin Endocrinol Metab;90.PP:493–500
12-Flower DR. (1996). The lipocalin protein family: structure and function. Biochemical Journal 318.PP: 1–14
13-Galic S, Oakhill JS & Steinberg GR. (2010) Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology 316 .PP 129 –139
14-Graham TE, Yang Q, Bluher M, Hammarstedt A, Ciaraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U & Kahn BB. (2006) Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. New England Journal of Medicine 354 PP.2552–2563
 
15. Hahn V, Halle M, Schmidt-Trucksass A, et al. (2009) Physical activity and the metabolic syndrome in elderly German men and women: results from the population-based KORA Survey. Diabetes Care; 32(3) PP:511-513.
16. Hosseinpanah, F. Barzin, M. Sarbakhsh, P. Eskandary,P. Azizi, MF.(2009) Trends of obesity and abdominal obesity in Tehranian adults: a cohort study. BMC Public Health, 9:426 .PP 1 –9.
17. Johnson JL, Slentz CA, Houmard JA , et al.(2007) Exercise training amount and intensity effects on metabolic syndrome. Am J Cardiol; PP:1759-66.
 
18- Jorge, MLMP. de Oliveira, VN. Resende, NM. Paraiso, LF Calixto, . A. Diniz, ALD. Resende, ES. Ropelle, ER. Carvalheira, JB. Espindola, FS. Jorgea, PT. Bruno Geloneze. (2011). The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. PP: 1244-1252
19- Kahn, Barbara B, Flier JS. (2000) Obesity and insulin resistance. J Clin Invest .PP: 106: 473-81
20-Kosti, RI. Panagiotakos, DB. (2006) the epidemic of obesity in childrenand adolescents in the world Cent Eur J Publ Health 14 (4).PP: 151–159
 
21- Ku YH, Han KA, Ahn H, Kwon H, Koo BK, Kim HC & Min KW. (2010). Resistance exercise did not alter intramuscular adipose tissue but reduced retinol-binding protein-4 concentration in individuals with type 2 diabetes mellitus. Journal of International Medical Research 38. PP:782–791
22- Laquatra I, Mahan LK,Scott-Stamp. S, Philadelphia, Saunders (2000) Nutrition for weight management -Stamp. S,In: Krause s Food Nutrition and Diet Therapy, PP: 482-509
23- Lim S, Choi SH, Jeong IK, et al. (2008) Insulin sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women. J Clin Endocrinol Metab; 93(6) .PP:2263-8.
 
24-Ludvik B,Nolan JJ, Baloga J, Sacks D, and Olefsky J. (1995). Effect of Obesity on insulin resistance in normal subjects and patents with NIDDM. Diabetes. 44. PP: 1121-1125
 
25-Nelson, Kim M. Huffman, Connie W. Bales, Joseph A. Houmard and William E. Kraus Lucy W. Piner, Victoria H. Hawk, Michael J. Muehlbauer, Greg P. Samsa, Rendon C. Cris A. Slentz, Lori A. Bateman, Leslie H. Willis, A. Tamlyn Shields, Charles J. Tanner (2011). Effects of aerobic vs. resistance training on visceral and liver fatstores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT Am J Physiol Endocrinol Metab 301. PP:1033-1039
26-No authors listed. (2000). National Task Force on the Prevention and Treatment of Obesity. Overweight, obesity, and health risk. Arch Intern Med., 160:PP 898 –904
27- Paolisso G, Tataranni P.A., Foley J.E.,Bogardus C., Howard B.V., Ravussin E. (1995) A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia; 38.PP: 1213–1217
28- Seidell JC, Verschuren WM, van Leer EM, Kromhout D (1996) Overweight, underweight, and mortality. A prospective study of 48, 287 men and women. Arch Intern Med 156. PP: 958–963
 
29- Sen Y, Kandemir N, Alikasifoglu A, Gonc N & Ozon A.( 2008). Prevalence and risk factors of metabolic syndrome in obese children and adolescents: the role of the severity of obesity. European Journal of Pediatrics 167. PP: 1183–1189
30- Taleghani HM, Soori R, Rezaeian, N. Khosravi N,(2012) Changes of plasma leptin and adiponectin levels in response to combined endurance and resistance training in sedentary postmenopausal women. 13(2). PP:269 – 277
 
31- Tremblay A, Simoneau JA, Bouchard C. (1994) Impact of exercise intensity on body fatness and skeletal muscle metabolism. Metabolism;43 PP: 814-8.
 
32- Tzanetakou,IP.. Katsilambros, NL. Benetos, A.. Mikhailidis, DP. Perrea, DN. (2012) Is obesity linked to aging?Adipose tissue and the role of telomeres Ageing Research Reviews 11.PP: 220– 229
 
33- Unger R.H., Zhou Y.T., Orci L., (1999) Regulation offatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci; 96.PP: 2327–2332.
 
34- Witteman JC, Willett WC, Stampfer MJ, Colditz GA, Sacks FM, Speizer FE, Rosner B, Hennekens CH(1989) A prospective study of nutritional factors and hypertension among U. S. women. Circulation 80.PP: 1320–1327
 
35- Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L & Kahn BB. (2005). Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature  436.PP:356–362
 
36- Zovich DC, Orologa A, Okuno M, Kong LW, Talmage DA, Piantedosi R, Goodman DS & Blaner WS. (1992). Differentiation-dependent expression of retinoid-binding proteins in BFC-1 beta adipocytes. Journal of Biological Chemistry  267 PP:13884 –13889