Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 PhD of Exersice Physiologhy, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

2 Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

3 . Associate Professor of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

4 . Professor, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran

5 . Associate Professor of Biochemistry, Cellular & Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran


The most important physiological role of apelin as a novel adipokine is co- relation with insulin hormone. The aim of this study was to investigate the effects of 12 weeks combined training on plasma apelin and insulin resistance index in overweight females. Therefore, 40 non athlete and over weight female students (BMI, 25-30), were selected and divided randomly in two experimental and control groups, equally. Training program was done seven days a week for 12 weeks. The endurance training program, which was performed four sessions per week, included intermittent running and walking. Two sessions per week were assigned to progressive resistance training consisted of circuit trainings. One session per week was also allocated to handball training. Blood samples were taken in fasting state from all subjects. Plasma apelin and insulin concentrates were determined by ELISA test. The statistical analyze of research was done by Repeated ANOVA (2×2), at the significance level of p


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