Document Type : Research Paper I Open Access I Released under CC BY-NC 4.0 license


1 Assistant Professor, Department of Sport Injury and Corrective Movements, Faculty of Physical Education and Sports Sciences, Allameh Tabataba’i University, Tehran, Iran

2 Associate Professor, Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahid Beheshti University, Tehran, Iran

3 PhD Student of Sport Physiology, Faculty of Physical Education and Sports Sciences, Shahid Beheshti University, Tehran, Iran

4 PhD Student of Sport Physiology, Faculty of Physical Education and Sports Sciences, Mazandaran University, Babolsar, Iran


The aim of the present study was to investigate the response of plasma visfatin to resistance exercise intensity and its relationship with insulin resistance, growth hormone and IL-6. After familiarization and determining their maximum strength (1-RM), 15 healthy young subjects (age: 26.2±4.1 yr, weight: 75.1±9.1 kg) performed three resistance exercise sessions at intensities of 30%, 55% and 80% of 1-RM with equal volumes randomly with a one-week interval. Blood samples were collected before and immediately after the exercise and analyzed to measure glucose, insulin, growth hormone, interlukin-6 (IL-6) and visfatin. Results showed no significant differences among the responses of plasma visfatin, interlukin-6 and insulin resistance index to three different resistance exercise intensities (P>0.05). Irrespective of intensity, a session of resistance exercise had a significant effect (P<0.001) on all variables except for visfatin. No significant relationships were found among all measured variables (P>0.05). Based on the findings of the present study, it could be concluded that resistance exercise intensity was not an effective factor for the response of visfatin, IL-6 and insulin resistance index which might be due to small differences in energy cost of resistance exercise at different intensities but equal volumes. Since there was no significant relationship between visfatin and insulin resistance in response to resistance exercise, this adipokine cannot be involved in insulin resistance during exercise.


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