An increase in c-reactive protein inflammatory indicator and lipid profile is accompanied with an increase in cardiovascular risks. However, the effect of resistance exercises on these cardiovascular risk factors in females is unknown.The aim of this study was to examine the effect of 12 weeks of circuit exercise on c-reactive protein and lipid profile in inactive women.For this purpose, 24 young inactive women (mean age of 26±3.50 years, height 160±2.50 cm and weight 62±6.93 kg) were selected voluntarily and divided randomly into two 12-subject groups (a control and an experimental). The exercise program included 12 weeks of circuit resistance exercise, 3 sessions a week, 20 to 60 minutes and 8 stations each session with 65-80% intensity of one repetition maximum (1RM). Blood samples were collected after 14 hours of fasting just before the project and also 48 hours after the last exercise session. Data were analyzed with Kolmogorov-Smirnov test (K-S test) and dependant and independent t tests at α≤0.05. The Results showed that after 12 weeks of circuit resistance exercise in the experimental group, the amounts of CRP, TG, TC, LDL-C, VLDL-C changed significantly (P≤0.05) while HDL-C did not change significantly (P≥0.05).Finally, it seems that circuit resistance exercise can be considered as an effective and valuable method to prevent and reduce cardiovascular diseases in women and to improve their health as it decreases risk factors.