Effect regular endurance exercises and galbanum supplement on vascular function during chronic hypertension in male Wistar rats

Document Type : Research Paper

Authors

1 Master in Exercise Physiology, Faculty of Physical Education ,University of Mazandaran-Babolsar Iran

2 Associate Professor of Exercise Physiology, Faculty of Physical Education ,University of Mazandaran-Babolsar, Iran

Abstract

Chronic inflammation is an integral part of cardiovascular disease and high blood pressure was found to be associated with endothelial dysfunction. The aim of this study was to evaluate the effect of endurance training and Galbanum supplement on parameters related to vascular function includes endothelial selectin(E-SELECTIN) and angiotensin converting enzyme inhibitor(ACE-I) as inflammatory factors and vasoconstriction and nitric oxide(NO) as a factor vasodilation during chronic hypertension induced by Nitro-L-arginine methyl ester(L-NAME) in male Wistar rats.
48 male Wistar rats were randomly divided into six groups; 1) basic, 2)sham, 3)L-NAME, 4)endurance training, 5)Galbanum and 6)training+Galbanum. Groups of 3 until 6, five times a week for eight weeks, 10 mg / kg L-NAME solutions were given. Also, rats in the sham group received saline in the same conditions. Groups of 4 and 6 were performed endurance running protocol on a treadmill speed of 15 to 20 meters per minute for 25 to 64 minutes 5 times a week for 8 weeks. Groups of 5 and 6 received 90 mg / kg dissolved Galbanum using gavage 5 times a week for 8 weeks. Infusion of L-NAME was led to hypertension, as was detected by significance decrease in ACE-I (p<0.00). Furthermore, hypertension was associated with increased NO and decreased E-SELECTIN. The training protocol significance reduces E-SELECTIN (p<0.00) and significance increased NO (p<0.04) in the 4 group and administration of Galbanum causes a decrease in E-SELECTIN (p<0.00) in the 5 group and combine training and galbanum causes a significance decrease in E-SELECTIN (p<0.00) and a significance increase in NO (p<0.03) in group of 6, as compared to L-NAME group in p<0.05 significance level. Chronic hypertension is associated with endothelial dysfunction and use of non-pharmacological strategies such as endurance training and Galbanum antioxidant supplementation probably through vascular endothelial function can cause controlled high blood pressure.

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