Exercise Training has been shown to decrease chronic low- grade systemic inflammation in high- fat diet induced obesity. However, the mechanisms mediating its beneficial effects are not fully understood. Therefore, the aim of this study was to investigate the effects of a 12- week endurance training on IL-6, IL-10 and nesfatin -1 in obese male rats. Sixteen male wistar rats (2 months old) were fed a high fat diet for 8 weeks, reaching an average weight of 319 ± 30g. The animals were randomly divided into control (n=8) and 12-week endurance training (T, n=8) groups. Training group was given exercise on motor- driven treadmill at 25 to 30 m/min (0% grade), 60 min/day, 5 days/week for 12 weeks, and both groups were given “ad libitum”. The Elisa method was used for laboratory analysis of Nesfatin-1, IL-6 and IL-10. The results revealed that the average weight of rats in T group was significantly lower than that of the control group (P=0.001). A significant decrease was also observed in IL-6 T group (P=0.04). Nesfatin – 1 plasma level increased in T group (P=0.001). Despite the fact that IL-10 was lower in T group, the difference was not significant. The results of present study showed that long- term endurance training led to an increase in the anti- inflammatory nesfatin -1, and nesfatin- 1 probably plays a role in energy balance, that is independent of the changes of IL-10 and IL-6 in plasma level.
Haghshenas,R , Ravasi,A A , Kordi,M R , Hedayati,M , Shabkhiz,F and Shariatzadeh,M . (2013). The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats. Sport Biosciences, 5(4), 109-122. doi: 10.22059/jsb.2013.35689
MLA
Haghshenas,R , , Ravasi,A A , , Kordi,M R , , Hedayati,M , , Shabkhiz,F , and Shariatzadeh,M . "The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats", Sport Biosciences, 5, 4, 2013, 109-122. doi: 10.22059/jsb.2013.35689
HARVARD
Haghshenas R, Ravasi A A, Kordi M R, Hedayati M, Shabkhiz F, Shariatzadeh M. (2013). 'The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats', Sport Biosciences, 5(4), pp. 109-122. doi: 10.22059/jsb.2013.35689
CHICAGO
R Haghshenas, A A Ravasi, M R Kordi, M Hedayati, F Shabkhiz and M Shariatzadeh, "The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats," Sport Biosciences, 5 4 (2013): 109-122, doi: 10.22059/jsb.2013.35689
VANCOUVER
Haghshenas R, Ravasi A A, Kordi M R, Hedayati M, Shabkhiz F, Shariatzadeh M. The Effect of a 12 -Week Endurance Training on IL-6, IL-10 and Nesfatin -1 Plasma Level of Obese Male Rats. SBio. 2013;5(4):109-122 (In Persian). doi: 10.22059/jsb.2013.35689
