Obesity is known to increase the risk for cardiovascular diseases. Serum levels of cellular adhesion molecules are reported to be indices of arthrosclerosis. So each intervention that has benefit effects on them is very important for general health. The purpose of this study was to determine the effect of high interval intensity training programs on ICAM-1. 18 sedentary obese males with MEAN ±SD age, %BF, weight and BMI: Exp 1 (20.55±1.34 y, 26.84±4.07, 93.05±9.02 kg and 31.20±3.33 Kg/m2) were randomly divided to two groups, the experimental and control groups. participated in 16 weeks of moderate to high intensity interval training (8-10 × 4 minutes sets of running at 60-90% of Reserve Heart Rate and 2 minutes rest interval at 40-50% of Reserve Heart Rate) three days per week. The blood sampling was performed after 18 fasting hours in baseline and 48 h after final training sessions with the same conditions. Resulting data were analyzed by independent-sample t test, person correlation coefficient and pair t-tests (?=0.05). Data analysis showed that ICAM-1 decreased in experimental group but only was significant in EXP 2 (p= 0.015).There was no relationship between baseline of sICAM-1 with physical variable and lipid profile (P >0.05). There was positive correlation between %BF and BFM changes and ICAM-1 changes (P <0.05).The TC, LDL-C and RF levels significantly decreased.