The Effect of Allium Paradoxum Extract Combined with Voluntary Wheel Running on Brain Amyloid Beta (Aβ1-42) Levels in Diabetic Male Rats

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Abstract

Protein amyloid beta (A?), as the pathologic hallmark of Alzheimer disease (AD), increases in the brain of diabetic patients. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running combined with allium paradoxum extract on cortex amyloid beta (A?1-42) levels in diabetic rats induced with alloxan. For this purpose, 42 male wistar rats (weight 185+1 gr, 8 weeks old) were assigned randomly to 6 groups (n=7): normal control (c), training (T), control – diabetic (CD), diabetic – training (DT), diabetic – allium (DA), diabetic – allium – training (DAT). Subjects were diabetes through alloxan injection (120 mg/kg dissolved in saline) intraperitoneally. Training and diabetic – training rats inhabited in cages performed their training voluntarily on a running wheel for six weeks. At the end of the protocol, cortex A?1-42 in T and DT groups decreased. A?1-42 levels significantly decreased in T and DT compared with C and CD respectively (P<0.001). Also, A?1-42 levels significantly increased in CD in comparison with C (P<0.001). Furthermore, voluntary training along with consumption of allium paradoxum extract decreased cortex A?1-42 in DAT (P<0.001). Voluntary training and allium extract had positive effects on decreasing A?1-42 levels; therefore, it can be recommended as therapeutic strategy for diabetes.

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