This study intended to compare the effect of consuming creatine and mixed creatine-carbohydrate supplementations on the anaerobic power and cellular damage indices (CK, LDH) in males aged between 15 and 18 in the city of Kouhrang. For this purpose, 36 subjects (mean age 16.42±0.90 yrs, weight 54.85±9.96 kg, and height 167.75±8.28 cm) were selected by available method. First, blood samples were collected to determine the baseline of creatine kinase and lactate dehydrogenase as cellular damage indices. Then, anaerobic power tests (Sergeant Jump, pair jump, medical ball throw, and dash) were performed. Next, the subjects were randomly divided into three 12-subject groups. The first experimental group consumed only carbohydrate; the second experimental group received creatine; and the third experimental group consumed a mixture of creatine and carbohydrate. Field practice was comprised of three sessions of weight training together with consumption of creatine and carbohydrate supplements for five days. Supplements, dissolved in water, were consumed four times a day: after breakfast, lunch, afternoon tea, and dinner. Then, immediately after the last day of practice, the blood samples were collected to measure the level of the above-mentioned enzymes. Two days later, anaerobic tests were administered once again to determine the effect of supplements. Descriptive and inferential statistics (one-way analysis of variance, Tokey post hoc test) and SPSS ver. 16 were used to analyze the data. The results showed that creatine improved the anaerobic power in the second experimental group (P<0.05). Moreover, this supplement significantly increased the level of creatine kinase and lactate dehydrogenase in this group (P<0.05). In the group who consumed carbohydrate besides creatine, anaerobic power significantly increased (P<0.001) while CK and LDH did not significantly increase. In carbohydrate group, no significant difference was observed in anaerobic power and CK and LDH levels. These findings indicated that creatine causes cellular damage and significantly increases creatine kinase and lactate dehydrogenase despite the positive effects on the anaerobic power while the mixture of creatine and carbohydrate increases anaerobic power and prevents cellular damage. Thus, it is recommended that athletes consume creatine along with carbohydrate to suffer fewer problems