The aim of this study was to determine the effect of eight-week resistance training on muscular strength and balance in men with multiple sclerosis (MS). For this purpose, out of 40 MS patients in Iran MS Society, 18 patients (mean age 34.05±7.8 yrs; mean expanded disability status scale 2.94±1.54 score; mean weight 67.83±11.58 kg; and mean body mass index 22.40±3.81kg/m2) were randomly divided to two groups: experimental (n=8) and control (n=10). Control group continued consuming disease specific medication, while experimental group participated in eight-week resistance training, three sessions/week, 60-80 minutes with 50%-70% of 1RM. The data were analyzed with SPSS-13 software and t student method (??0.05). The result of t test showed that resistance training significantly increased leg extensor strength (p=0.001), knee extensors strength (p=0.001), chest press strength (p=0.001), seated rowing strength (p=0.001), and balance (p=0.023). The results of this study showed that resistance training appeared to be a well tolerated intervention to improve strength and balance and MS patients are capable of positive adaptations to resistance training associated with increasing muscular strength and balance. Finally, the result suggested that male patients with MS can use resistance training to improve their muscular strength and balance.