The Effect of 8 Weeks of Selective Exercise Activity and Estrogen Supplement on Satellite Cells in Ovariectomized Rats



The aim of this study was to investigate the effect of 8 weeks of selective exercise activity and estrogen supplement on satellite cells in ovariectomized sprague-dawley rats. At first, subjects were ovariectomized and after one month of complete recovery, they were randomly divided into four groups: Control, Exercise activity, Estrogen supplement, and Exercise and Estrogen supplement. Only exercise and exercise and estrogen groups performed a selective exercise activity for 8 weeks and during this period, estrogen and exercise and estrogen groups were implanted subcutaneously with 0.6 ml estrogen supplement. The obtained data were analyzed using one-way ANOVA. The research results indicated that exercise activity group showed a 1.5 times increase in the number of satellite cells while in exercise and estrogen and estrogen groups they decreased by 68% and 73.9% respectively. Moreover, obtained results demonstrated that observed changes in the number of satellite cells were significant only in exercise group. Aerobic exercise can increase the proliferation of satellite cells in the soleus muscle of rats. This increase in the number of satellite cells is the result of function of the distance running. This study indicated that endurance training can be used as a precondition for increasing muscle volume and improving muscle function.